Objective To investigate the prevalence and antibiotic resistance of Haemophilus influenza in children, and provide a guidline for prevention , clinical diagnosis and rational use of antibiotics. Methods 249 strains of Haemophilus influenza from various clinical specimens were col ected from the Third hospital of Changsha , the First hospital of Changsha and Changsha Central Hospital from Jan 2013 to Feb 2014.Al of them were identified by VITEK 2 com-pact .The antimicrobial susceptibility testing was performed by Kirby- Bauer disc diffusion method,and the nitrocefin phenol test was performed byβ- lacta-mase test. Results Results The isolation rate of Haemophilus influenza in winter and in spring was higher,were 38.15%and 29.32%.there was a high influenza rate in children from 1 to 3 years old. Haemophilus influenza was resistant to ampicil in ,compound sulfamethoxazole and cefuroxime, were81.12%,63.45%and 38.96% , while was sensitive to ampicil in/sulbactam,cefatriaxone,cefotaxime,ciprofloxacin,lomefloxacin,ofloxacin,evofloxacin,tetracycline. Conclutions Haemophilus influenza is resistant to ampicil in and compound sulfamethoxazole,while making it a priority to beta- lactamase inhibitor ,cephalosporins and azithromycin.
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