N6-adenosine methylation and the regulatory mechanism on LINE-1
Long interspersed elements-1(LINE-1)is the only autonomous transposon in human genome,and its retrotransposition results in change of cellular genome structure and function,leading occurrence of various severe diseases.As a central key intermediated component during life cycle of LINE-1 retrotransposition,the host modification of LINE-1 mRNA affects the LINE-1 transposition directly.N6-adenosine methylation(m6A),the most abundant epigenetic modification on eukaryotic RNA,is dynamically reversible.m6A modification is also found on LINE-1 mRNA,and it participants regulation of the whole LINE-1 replication cycle,with affecting LINE-1 retrotransposition as well as its adjacent genes expression,followed by influencing genomic stability,cellular self-renewal,and differentiation potential,which plays important roles in human development and diseases.In this review,we summarize the research progress in LINE-1 m6A modification,including its modification positions,patterns and related mechanisms,hoping to provide a new sight on the mechanism research and treatment of related diseases.
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