组蛋白变体H2A.Z的转录调控功能与动态作用机制
The roles and mechanisms of histone variant H2 A.Z in transcriptional regulation
孙朝冉 1吴旭东1
作者信息
- 1. 天津医科大学基础医学院,天津市医学表观遗传学重点实验室,天津 300070
- 折叠
摘要
H2A.Z是组蛋白H2A常见的组蛋白变体.近年来,人们通过多学科手段探究了 H2A.Z对于基因转录的激活或抑制作用.本文在概述组蛋白变体和H2A.Z发展史的基础上,重点阐述了 H2A.Z不同亚型、不同翻译后修饰和基因组分布在转录调控过程中的作用,明确了其生物学意义和在肿瘤发生发展、神经系统分化发育过程中的病理生理学意义,并总结了 H2A.Z在染色质沉积或者移除的动态调控机制方面的研究进展,以期为深入了解组蛋白变体的多样性,并为寻找相关疾病诊疗的新靶点提供参考.
Abstract
H2A.Z,one of the most well-known variants of histone H2A,has been extensively investigated on its dual roles in gene transcription in recent years.In this review,we focus on the intricate involvement of H2A.Z in transcriptional regulation,including the assembly of distinct H2A.Z subtypes,post-translational modifications and genomic distributions.Emphasis is placed on the biological and pathophysiological implications,particularly in tumorigenesis and nervous system development.We summarize the dynamic regulatory mechanisms governing H2A.Z deposition or eviction on chromatin to provide insights for understanding the diversity of histone variants and promoting the search of new targets in concerned disease diagnosis and treatment.
关键词
表观遗传调控/核小体/基因转录/组蛋白变体/H2A.ZKey words
epigenetic regulation/nucleosome/gene transcription/histone variant/H2A.Z引用本文复制引用
基金项目
国家自然科学基金(31870725)
国家自然科学基金(32071204)
出版年
2024
NETL
NSTL
万方数据