The mechanism and related research progress of GLP-1 receptor agonists in treating Alzheimer's disease
GLP-1 receptor agonists are primarily used clinically for the treatment of type 2 diabetes and have the potential for weight loss,while they are currently expanding their horizons in the treatment of hypertension,non-alcoholic liver disease,depression,and neurodegenerative diseases.In particular,in the treatment of Alzheimer's disease,a large number of animal models and a handful of clinical studies have demonstrated the potential efficacy of GLP-1 receptor agonists,making it highly probable that they will become a new entrant in the drug list for Alzheimer's disease.At present,the research on the mechanism of GLP-1 receptor agonist in the treatment of Alzheimer's disease is mainly based on in-depth analysis of the pathogenesis of Alzheimer's disease and exploration of the mechanism of its comorbidity with diabetes.This article mainly reviews the latest advances in the mechanism of GLP-1 receptor agonists in the treatment of Alzheimer's disease,introduces the latest achievements in animal studies and clinical studies,and aims to provide reference for the subsequent relevant basic research and clinical application.
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