Tobacco alkaloids:oral properties and sensory responses in e-cigarette aerosols
In order to study the influences of tobacco alkaloids on e-cigarette’s sensory responses, the olfactory, gustatory and chemesthetic properties of eight tobacco alkaloids were investigated, and their sensory responses in e-cigarette aerosols were evaluated by replacing nicotine with these minor alkaloids in e-cigarette individually. The sensory detection thresholds of tobacco alkaloids were measured according to the three alternative-forced-choice (3-AFC) procedure described in GB/T 22366—2008. The results showed that: 1) Tobacco alkaloids exhibited roast and floral notes as well as an alkaline odor. Within the concentration range set by FDA regulations, nicotine possessed a pure pungent sensation, while the minor alkaloids might evoke bitterness and pungency. In terms of the sensory detection threshold, nicotine was much lower than minor alkaloids and found to be 7 × 10-6 mg/mL. 2) Myosmine and nicotyrine greatly influenced the aroma of e-cigarettes, while throat impact and irritation were significantly decreased by using minor alkaloids as the nicotine source in e-cigarettes, and a decrease in sweetness originated from excipients in oral cavity was discerned. Therefore, tobacco alkaloids have various effects on e-cigarette’s sensory responses depending on their own inherent olfactory, gustatory and chemesthetic properties.