首页|Microbiome and metabolome dysbiosis analysis in impaired glucose tolerance for the prediction of progression to diabetes mellitus

Microbiome and metabolome dysbiosis analysis in impaired glucose tolerance for the prediction of progression to diabetes mellitus

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Gut microbiota and circulating metabolite dysbiosis predate important pathological changes in glucose metabolic disorders;however,comprehensive studies on impaired glucose tolerance(IGT),a diabetes mellitus(DM)precursor,are lacking.Here,we perform metagenomic sequencing and metabolomics on 47 pairs of individuals with IGT and newly diagnosed DM and 46 controls with normal glucose tolerance(NGT);patients with IGT are followed up after 4 years for progression to DM.Analysis of baseline data reveals significant differences in gut microbiota and serum metabolites among the IGT,DM,and NGT groups.In addition,13 types of gut microbiota and 17 types of circulating metabolites showed significant differences at baseline before IGT progressed to DM,including higher levels of Eggerthella unclassified,Coprobacillus unclassified,Clostridium ramosum,L-valine,L-norleucine,and L-isoleucine,and lower levels of Eubacte-rium eligens,Bacteroides faecis,Lachnospiraceae bacterium 3_1_46FAA,Alistipes senegalensis,Mega-spaera elsdenii,Clostridium perfringens,α-linolenic acid,10E,12Z-octadecadienoic acid,and dodecanoic acid.A random forest model based on differential intestinal microbiota and circulating metabolites can predict the progression from IGT to DM(AUC=0.87).These results suggest that microbiome and metabolome dysbiosis occur in individuals with IGT and have important predictive values and potential for intervention in preventing IGT from progressing to DM.

Impaired glucose toleranceDiabetes mellitusGut microbiotaMetabolomics

Boxun Zhang、Xuan Zhang、Zhen Luo、Jixiang Ren、Xiaotong Yu、Haiyan Zhao、Yitian Wang、Wenhui Zhang、Weiwei Tian、Xiuxiu Wei、Qiyou Ding、Haoyu Yang、Zishan Jin、Xiaolin Tong、Jun Wang、Linhua Zhao

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Institute of Metabolic Diseases,Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China

Faculty of Biological Science and Technology,Baotou Teachers College,Baotou,Inner Mongolia 014030,China

CAS Key Laboratory of Pathogenic Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences,Beijing 100101,China

Infinitus(China)Company Ltd,Guangzhou,Guangdong 510405,China

Affiliated Hospital of Changchun University of Chinese Medicine,Changchun,Jilin 130021,China

Department of Endocrinology,Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China

Xinjiekou Community Health Service Center in Xicheng District,Beijing 100035,China

Department of Spleen and Stomach,Shenzhen Traditional Chinese Medicine Hospital,Shenzhen,Guangdong 518033,China

University of Chinese Academy of Sciences,Beijing 100049,China

Beijing University of Chinese Medicine,Beijing 100105,China

Northeast Asia Institute of Traditional Chinese Medicine,Changchun University of Chinese Medicine,Changchun,Jilin 130117,China

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Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese MedicineNational Natural Science Foundation of China

ZYYCXTD-D-20200182104835

2024

10.1016/j.jgg.2023.08.005

遗传学报
中国遗传学会 中国科学院遗传与发育生物学研究所

遗传学报

CSTPCD
影响因子：0.821
ISSN：1673-8527
年,卷(期)：2024.51(1)
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