Department of Endocrine and Metabolic Diseases,Shanghai Institute of Endocrine and Metabolic Diseases,National Clinical Research Centre for Metabolic Diseases,State Key Laboratory of Medical Genomics,Research Unit of Clinical and Basic Research on Metabolic Diseases of Chinese Academy of Medical Sciences,Ruijin Yangtze River Delta Health Institute,Wuxi Branch of Ruijin Hospital,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China

National Research Center for Translational M

BGI-ShenZhen,Shenzhen,Guangdong 518083,China

National Research Center for Translational Medicine,National Key Scientific Infrastructure for Translational Medicine,Shanghai Jiao Tong University,Shanghai 200240,China

D epartment of Endocrine and Metabolic Diseases,Shanghai Institute of Endocrine and Metabolic Diseases,National Clinical Research Centre for Metabolic Diseases,State Key Laboratory of Medical Genomics,Research Unit of Clinical and Basic Research on Metabolic Diseases of Chinese Academy of Medical Sciences,Ruijin Yangtze River Delta Health Institute,Wuxi Branch of Ruijin Hospital,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China