首页|Unraveling the complexity of polycystic ovary syndrome with animal models

Unraveling the complexity of polycystic ovary syndrome with animal models

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Polycystic ovary syndrome(PCOS)is a highly familial and heritable endocrine disorder.Over half of the daughters born to women with PCOS may eventually develop their own PCOS-related symptoms.Progress in the treatment of PCOS is currently hindered by the complexity of its clinical manifestations and incomplete knowledge of its etiopathogenesis.Various animal models,including experimentally induced,naturally occurring,and spontaneously arising ones,have been established to emulate a wide range of phenotypical and pathological traits of human PCOS.These studies have led to a paradigm shift in un-derstanding the genetic,developmental,and evolutionary origins of this disorder.Furthermore,emerging evidence suggests that animal models are useful in evaluating state-of-the-art drugs and treatments for PCOS.This review aims to provide a comprehensive summary of recent studies of PCOS in animal models,highlighting the power of these disease models in understanding the biology of PCOS and aiding high-throughput approaches.

Polycystic ovary syndromeAnimal modelGenetic manipulationDevelopmental programmingDrug screening

Huanju Liu、Mixue Tu、Zhiyong Yin、Dan Zhang、Jun Ma、Feng He

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Center for Genetic Medicine,The Fourth Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang 310058,China

Key Laboratory of Women's Reproductive Health of Zhejiang Province and Department of Reproductive Endocrinology,Women's Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang 310006,China

Zhejiang Provincial Clinical Research Center for Child Health,Women's Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang 310006,China

Clinical Research Center on Birth Defect Prevention and Intervention of Zhejiang Province,Hangzhou,Zhejiang 310006,China

Institute of Genetics,Zhejiang University International School of Medicine,Hangzhou,Zhejiang 310058,China

Zhejiang Provincial Key Laboratory of Genetic and Developmental Disorder,Hangz

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National Key R&D Program of ChinaNational Key R&D Program of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of China

2021YFC27004032018YFA08001023187124931871452

2024

10.1016/j.jgg.2023.09.012

遗传学报
中国遗传学会 中国科学院遗传与发育生物学研究所

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CSTPCD
影响因子：0.821
ISSN：1673-8527
年,卷(期)：2024.51(2)
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