首页|Current therapies for osteoarthritis and prospects of CRISPR-based genome,epigenome,and RNA editing in osteoarthritis treatment

Current therapies for osteoarthritis and prospects of CRISPR-based genome,epigenome,and RNA editing in osteoarthritis treatment

扫码查看
原文链接
  • 万方数据
  • 维普
Osteoarthritis(OA)is one of the most common degenerative joint diseases worldwide,causing pain,disability,and decreased quality of life.The balance between regeneration and inflammation-induced degradation results in multiple etiologies and complex pathogenesis of OA.Currently,there is a lack of effective therapeutic strategies for OA treatment.With the development of CRISPR-based genome,epi-genome,and RNA editing tools,OA treatment has been improved by targeting genetic risk factors,acti-vating chondrogenic elements,and modulating inflammatory regulators.Supported by cell therapy and in vivo delivery vectors,genome,epigenome,and RNA editing tools may provide a promising approach for personalized OA therapy.This review summarizes CRISPR-based genome,epigenome,and RNA editing tools that can be applied to the treatment of OA and provides insights into the development of CRISPR-based therapeutics for OA treatment.Moreover,in-depth evaluations of the efficacy and safety of these tools in human OA treatment are needed.

OsteoarthritisGenome editingEpigenome editingRNA editing

Yuxi Chen、Xiao Luo、Rui Kang、Kaixin Cui、Jianping Ou、Xiya Zhang、Puping Liang

展开 >

MOE Key Laboratory of Gene Function and Regulation,State Key Laboratory of Biocontrol,School of Life Sciences,Sun Yat-sen University,Guangzhou,Guangdong 510275,China

Center for Reproductive Medicine,The Third Affiliated Hospital of Sun Yat-sen University,Sun Yat-sen University,Guangzhou,Guangdong 510630,China

National Natural Science FoundationNational Natural Science FoundationGuangdong Special Support ProgramGuangdong Basic and Applied Basic Research FoundationGuangdong Basic and Applied Basic Research FoundationMOE Key Laboratory of Gene Function and RegulationGuangzhou Science and Technology Planning ProjectGuangzhou Science and Technology Planning ProjectFundamental Research Funds for the Central Universities,Sun Yatsen University

32001063822017692019BT02Y2762021A15150107592023A15150101762022010204112023A04J195223ptpy59

2024

10.1016/j.jgg.2023.07.007

遗传学报
中国遗传学会 中国科学院遗传与发育生物学研究所

遗传学报

CSTPCD
影响因子：0.821
ISSN：1673-8527
年,卷(期)：2024.51(2)
  • 468