Abstract
Messenger RNA(mRNA)translation consists of initiation,elongation,termination,and ribosome recycling,carried out by the translation machinery,primarily including tRNAs,ribosomes,and translation factors(TrFs).Translational regulators transduce signals of growth and development,as well as biotic and abiotic stresses,to the translation machinery,where global or selective translational control occurs to modulate mRNA translation efficiency(TrE).As the basis of translational control,the translation machinery directly determines the quality and quantity of newly synthesized peptides and,ultimately,the cellular adaption.Thus,regulating the availability of diverse machinery components is reviewed as the central strategy of translational control.We provide classical signaling pathways(e.g.,integrated stress responses)and cellular behaviors(e.g.,liquid-liquid phase separation)to exemplify this strategy within different physio-logical contexts,particularly during host-microbe interactions.With new technologies developed,further understanding this strategy will speed up translational medicine and translational agriculture.
基金项目
National Natural Science Foundation of China(32070284)
Major Project of Hubei Hongshan Laboratory(2022hszd016)
Key Research and Development Program of Hubei Province(2022BFE003)
NETL
NSTL
万方数据