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Translation machinery:the basis of translational control

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Messenger RNA(mRNA)translation consists of initiation,elongation,termination,and ribosome recycling,carried out by the translation machinery,primarily including tRNAs,ribosomes,and translation factors(TrFs).Translational regulators transduce signals of growth and development,as well as biotic and abiotic stresses,to the translation machinery,where global or selective translational control occurs to modulate mRNA translation efficiency(TrE).As the basis of translational control,the translation machinery directly determines the quality and quantity of newly synthesized peptides and,ultimately,the cellular adaption.Thus,regulating the availability of diverse machinery components is reviewed as the central strategy of translational control.We provide classical signaling pathways(e.g.,integrated stress responses)and cellular behaviors(e.g.,liquid-liquid phase separation)to exemplify this strategy within different physio-logical contexts,particularly during host-microbe interactions.With new technologies developed,further understanding this strategy will speed up translational medicine and translational agriculture.

Translational controlRibosometRNATranslation machineryuORFPhase separationImmune response

Shu Yuan、Guilong Zhou、Guoyong Xu

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State Key Laboratory of Hybrid Rice,Institute for Advanced Studies(IAS),Wuhan University,Wuhan,Hubei 430072,China

Hubei Hongshan Laboratory,Wuhan,Hubei 430070,China

National Natural Science Foundation of ChinaMajor Project of Hubei Hongshan LaboratoryKey Research and Development Program of Hubei Province

320702842022hszd0162022BFE003

2024

10.1016/j.jgg.2023.07.009

遗传学报
中国遗传学会 中国科学院遗传与发育生物学研究所

遗传学报

CSTPCD
影响因子：0.821
ISSN：1673-8527
年,卷(期)：2024.51(4)
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