首页|Genome engineering of the human gut microbiome

Genome engineering of the human gut microbiome

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The human gut microbiome,a complex ecosystem,significantly influences host health,impacting crucial aspects such as metabolism and immunity.To enhance our comprehension and control of the molecular mechanisms orchestrating the intricate interplay between gut commensal bacteria and human health,the exploration of genome engineering for gut microbes is a promising frontier.Nevertheless,the complexities and diversities inherent in the gut microbiome pose substantial challenges to the development of effective genome engineering tools for human gut microbes.In this comprehensive review,we provide an overview of the current progress and challenges in genome engineering of human gut commensal bacteria,whether executed in vitro or in situ.A specific focus is directed towards the advancements and prospects in cargo DNA delivery and high-throughput techniques.Additionally,we elucidate the immense potential of genome engineering methods to enhance our understanding of the human gut microbiome and engineer the mi-croorganisms to enhance human health.

Non-model gut commensalsGenome editing reagentsCargo deliveryHigh-throughput genome engineering

Linggang Zheng、Juntao Shen、Ruiyue Chen、Yucan Hu、Wei Zhao、Elaine Lai-Han Leung、Lei Dai

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Dr Neher's Biophysics Laboratory for Innovative Drug Discovery/State Key Laboratory of Quality Research in Chinese Medicine,Macau University of Science and Technology,Taipa,Macau 999078,China

CAS Key Laboratory of Quantitative Engineering Biology,Shenzhen Institute of Synthetic Biology,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China

University of Chinese Academy of Sciences,Beijing 100049,China

Cancer Center,Faculty of Health Science,University of Macau,Macau 999078,China

MOE Frontiers Science Center for Precision Oncology,University of Macau,Macau 999078,China

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国家重点研发计划Guangdong Basic and Applied Basic Research FoundationDr.Neher's Biophysics Laboratory for Innovative Drug Discoveryregular grants from Macao Science and Technology Development FundYoung Qihuang Scholar funded by National Administration of Traditional Chinese Medicine(2020)Startup Research Grant of University of MacauFaculty of Health Sciences,University of Macau

2019YFA09067002020A1515110184001/2020/ALC0056/2020/AMJ & 0063/2022/A2SRG2022-00020-FHS

2024

10.1016/j.jgg.2024.01.002

遗传学报
中国遗传学会 中国科学院遗传与发育生物学研究所

遗传学报

CSTPCD
影响因子：0.821
ISSN：1673-8527
年,卷(期)：2024.51(5)
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