Distinguished biological adaptation architecture aggravated population differentiation of Tibeto-Burman-speaking people

Yuntao Sun ¹Mengge Wang ²Qiuxia Sun ³Yan Liu ⁴Shuhan Duan ⁵Zhiyong Wang ⁶Yunyu Zhou ⁷Jun Zhong ⁸Yuguo Huang ⁹Xinyu Huang ¹⁰Qingxin Yang ¹¹Xiangping Li ⁶Haoran Su ⁵Yan Cai ¹²Xiucheng Jiang ⁵Jing Chen ¹³Jiangwei Yan ¹⁴Shengjie Nie ¹¹Liping Hu ¹¹Junbao Yang ¹⁵Renkuan Tang ¹⁶Chuan-Chao Wang ¹⁷Chao Liu ¹⁸Xiaohui Deng ¹⁰Libing Yun ¹⁹Guanglin He²⁰

扫码查看

作者信息

1. West China School of Basic Science & Forensic Medicine,Sichuan University,Chengdu,Sichuan 610041,China;Institute of Rare Diseases,West China Hospital of Sichuan University,Sichuan University,Chengdu,Sichuan 610000,China;Center for Archaeological Science,Sichuan University,Chengdu,Sichuan 610000,China
2. Institute of Rare Diseases,West China Hospital of Sichuan University,Sichuan University,Chengdu,Sichuan 610000,China;Center for Archaeological Science,Sichuan University,Chengdu,Sichuan 610000,China;Faculty of Forensic Medicine,Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou,Guangdong 510275,China;Guangzhou Forensic Science Institute,Guangzhou,Guangdong 510055,China
3. Institute of Rare Diseases,West China Hospital of Sichuan University,Sichuan University,Chengdu,Sichuan 610000,China;Department of Forensic Medicine,College of Basic Medicine,Chongqing Medical University,Chongqing 400331,China
4. Institute of Rare Diseases,West China Hospital of Sichuan University,Sichuan University,Chengdu,Sichuan 610000,China;School of Clinical Medical Sciences,North Sichuan Medical College,Nanchong,Sichuan 637100,China
5. Institute of Rare Diseases,West China Hospital of Sichuan University,Sichuan University,Chengdu,Sichuan 610000,China;School of Basic Medical Sciences,North Sichuan Medical College,Nanchong,Sichuan 637100,China
6. Institute of Rare Diseases,West China Hospital of Sichuan University,Sichuan University,Chengdu,Sichuan 610000,China;School of Forensic Medicine,Kunming Medical University,Kunming,Yunnan 650500,China
7. School of Stomatology,North Sichuan Medical College,Nanchong,Sichuan 637100,China
8. School of Basic Medical Sciences,North Sichuan Medical College,Nanchong,Sichuan 637100,China
9. Institute of Rare Diseases,West China Hospital of Sichuan University,Sichuan University,Chengdu,Sichuan 610000,China
10. West China School of Basic Science & Forensic Medicine,Sichuan University,Chengdu,Sichuan 610041,China
11. School of Forensic Medicine,Kunming Medical University,Kunming,Yunnan 650500,China
12. School of Basic Medical Sciences,North Sichuan Medical College,Nanchong,Sichuan 637100,China;Department of Medical Laboratory,North Sichuan Medical College,Nanchong,Sichuan 637007,China
13. Institute of Rare Diseases,West China Hospital of Sichuan University,Sichuan University,Chengdu,Sichuan 610000,China;School of Forensic Medicine,Shanxi Medical University,Jinzhong,Shanxi,030600,China
14. School of Forensic Medicine,Shanxi Medical University,Jinzhong,Shanxi,030600,China
15. School of Clinical Medical Sciences,North Sichuan Medical College,Nanchong,Sichuan 637100,China
16. Department of Forensic Medicine,College of Basic Medicine,Chongqing Medical University,Chongqing 400331,China
17. School of Life Sciences,Xiamen University,Xiamen,Fujian 361005,China
18. Anti-Drug Technology Center of Guangdong Province,Guangzhou,Guangdong 510230,China
19. West China School of Basic Science & Forensic Medicine,Sichuan University,Chengdu,Sichuan 610041,China;Center for Archaeological Science,Sichuan University,Chengdu,Sichuan 610000,China
20. Institute of Rare Diseases,West China Hospital of Sichuan University,Sichuan University,Chengdu,Sichuan 610000,China;Center for Archaeological Science,Sichuan University,Chengdu,Sichuan 610000,China
折叠

Abstract

Tibeto-Burman(TB)people have endeavored to adapt to the hypoxic,cold,and high-UV high-altitude environments in the Tibetan Plateau and complex disease exposures in lowland rainforests since the late Paleolithic period.However,the full landscape of genetic history and biological adaptation of geographi-cally diverse TB-speaking people,as well as their interaction mechanism,remain unknown.Here,we generate a whole-genome meta-database of 500 individuals from 39 TB-speaking populations and present a comprehensive landscape of genetic diversity,admixture history,and differentiated adaptative features of geographically different TB-speaking people.We identify genetic differentiation related to geography and language among TB-speaking people,consistent with their differentiated admixture process with incoming or indigenous ancestral source populations.A robust genetic connection between the Tibetan-Yi corridor and the ancient Yellow River people supports their Northern China origin hypothesis.We finally report substructure-related differentiated biological adaptative signatures between highland Tibetans and Loloish speakers.Adaptative signatures associated with the physical pigmentation(EDAR and SLC24A5)and metabolism(ALDH9A1)are identified in Loloish people,which differed from the high-altitude adaptative genetic architecture in Tibetan.TB-related genomic resources provide new insights into the genetic basis of biological adaptation and better reference for the anthropologically informed sampling design in biomedical and genomic cohort research.

Key words

Tibeto-Burman people/Genetic profile/Natural selection/Genetic diversity/Biological adaptation

引用本文复制引用

基金项目

国家自然科学基金(82202078)

Center for Archaeological Science of Sichuan University(23SASA01)

出版年

2024

遗传学报

中国遗传学会中国科学院遗传与发育生物学研究所

遗传学报

CSTPCD

影响因子：0.821

ISSN：1673-8527

参考文献量99

段落导航