首页|Distinguished biological adaptation architecture aggravated population differentiation of Tibeto-Burman-speaking people

Distinguished biological adaptation architecture aggravated population differentiation of Tibeto-Burman-speaking people

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Tibeto-Burman(TB)people have endeavored to adapt to the hypoxic,cold,and high-UV high-altitude environments in the Tibetan Plateau and complex disease exposures in lowland rainforests since the late Paleolithic period.However,the full landscape of genetic history and biological adaptation of geographi-cally diverse TB-speaking people,as well as their interaction mechanism,remain unknown.Here,we generate a whole-genome meta-database of 500 individuals from 39 TB-speaking populations and present a comprehensive landscape of genetic diversity,admixture history,and differentiated adaptative features of geographically different TB-speaking people.We identify genetic differentiation related to geography and language among TB-speaking people,consistent with their differentiated admixture process with incoming or indigenous ancestral source populations.A robust genetic connection between the Tibetan-Yi corridor and the ancient Yellow River people supports their Northern China origin hypothesis.We finally report substructure-related differentiated biological adaptative signatures between highland Tibetans and Loloish speakers.Adaptative signatures associated with the physical pigmentation(EDAR and SLC24A5)and metabolism(ALDH9A1)are identified in Loloish people,which differed from the high-altitude adaptative genetic architecture in Tibetan.TB-related genomic resources provide new insights into the genetic basis of biological adaptation and better reference for the anthropologically informed sampling design in biomedical and genomic cohort research.

Tibeto-Burman peopleGenetic profileNatural selectionGenetic diversityBiological adaptation

Yuntao Sun、Mengge Wang、Qiuxia Sun、Yan Liu、Shuhan Duan、Zhiyong Wang、Yunyu Zhou、Jun Zhong、Yuguo Huang、Xinyu Huang、Qingxin Yang、Xiangping Li、Haoran Su、Yan Cai、Xiucheng Jiang、Jing Chen、Jiangwei Yan、Shengjie Nie、Liping Hu、Junbao Yang、Renkuan Tang、Chuan-Chao Wang、Chao Liu、Xiaohui Deng、Libing Yun、Guanglin He

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West China School of Basic Science & Forensic Medicine,Sichuan University,Chengdu,Sichuan 610041,China

Institute of Rare Diseases,West China Hospital of Sichuan University,Sichuan University,Chengdu,Sichuan 610000,China

Center for Archaeological Science,Sichuan University,Chengdu,Sichuan 610000,China

Faculty of Forensic Medicine,Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou,Guangdong 510275,China

Guangzhou Forensic Science Institute,Guangzhou,Guangdong 510055,China

Department of Forensic Medicine,College of Basic Medicine,Chongqing Medical University,Chongqing 400331,China

School of Clinical Medical Sciences,North Sichuan Medical College,Nanchong,Sichuan 637100,China

School of Basic Medical Sciences,North Sichuan Medical College,Nanchong,Sichuan 637100,China

School of Forensic Medicine,Kunming Medical University,Kunming,Yunnan 650500,China

School of Stomatology,North Sichuan Medical College,Nanchong,Sichuan 637100,China

Department of Medical Laboratory,North Sichuan Medical College,Nanchong,Sichuan 637007,China

School of Forensic Medicine,Shanxi Medical University,Jinzhong,Shanxi,030600,China

School of Life Sciences,Xiamen University,Xiamen,Fujian 361005,China

Anti-Drug Technology Center of Guangdong Province,Guangzhou,Guangdong 510230,China

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国家自然科学基金Center for Archaeological Science of Sichuan University

8220207823SASA01

2024

10.1016/j.jgg.2023.10.002

遗传学报
中国遗传学会 中国科学院遗传与发育生物学研究所

遗传学报

CSTPCD
影响因子：0.821
ISSN：1673-8527
年,卷(期)：2024.51(5)
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