遗传学报2024，Vol.51Issue(6) ：608-616.DOI:10.1016/j.jgg.2024.02.007

Fulminant myocarditis induced by SARS-CoV-2 infection without severe lung involvement:insights into COVID-19 pathogenesis

Han Du Zhongtao Du Liang Wang Hong Wang Mingjun Jia Chunge Zhang Yun Liu Cheng Zhang Ya Zhang Ruifeng Zhang Shuang Zhang Ning Zhang Zhenghai Ma Chen Chen Wenjun Liu Hui Zeng George F.Gao Xiaotong Hou Yuhai Bi
遗传学报2024，Vol.51Issue(6) ：608-616.DOI:10.1016/j.jgg.2024.02.007
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  • NETL
  • NSTL
  • 万方数据

Fulminant myocarditis induced by SARS-CoV-2 infection without severe lung involvement:insights into COVID-19 pathogenesis

Han Du 1Zhongtao Du 2Liang Wang 3Hong Wang 2Mingjun Jia 4Chunge Zhang 5Yun Liu 4Cheng Zhang 1Ya Zhang 3Ruifeng Zhang 3Shuang Zhang 3Ning Zhang 3Zhenghai Ma 6Chen Chen 7Wenjun Liu 5Hui Zeng 7George F.Gao 8Xiaotong Hou 2Yuhai Bi8
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作者信息

  • 1. College of Life Science and Technology,Xinjiang University,Urumchi,Xinjiang 830046,China;CAS Key Laboratory of Pathogen Microbiology and Immunology,Institute of Microbiology,Center for Influenza Research and Early-warning(CASCIRE),CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID),Chinese Academy of Sciences,Beijing 100101,China
  • 2. Beijing Anzhen Hospital,Capital Medical University,Beijing 100029,China
  • 3. CAS Key Laboratory of Pathogen Microbiology and Immunology,Institute of Microbiology,Center for Influenza Research and Early-warning(CASCIRE),CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID),Chinese Academy of Sciences,Beijing 100101,China
  • 4. CAS Key Laboratory of Pathogen Microbiology and Immunology,Institute of Microbiology,Center for Influenza Research and Early-warning(CASCIRE),CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID),Chinese Academy of Sciences,Beijing 100101,China;College of Veterinary Medicine,Shanxi Agricultural University,Taiyuan,Shanxi 030031,China
  • 5. CAS Key Laboratory of Pathogen Microbiology and Immunology,Institute of Microbiology,Center for Influenza Research and Early-warning(CASCIRE),CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID),Chinese Academy of Sciences,Beijing 100101,China;University of Chinese Academy of Sciences,Beijing 100049,China
  • 6. College of Life Science and Technology,Xinjiang University,Urumchi,Xinjiang 830046,China
  • 7. Beijing Shijitan Hospital,Capital Medical University,Beijing 100038,China
  • 8. College of Life Science and Technology,Xinjiang University,Urumchi,Xinjiang 830046,China;CAS Key Laboratory of Pathogen Microbiology and Immunology,Institute of Microbiology,Center for Influenza Research and Early-warning(CASCIRE),CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID),Chinese Academy of Sciences,Beijing 100101,China;University of Chinese Academy of Sciences,Beijing 100049,China
  • 折叠

Abstract

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection often leads to pulmonary com-plications.Cardiovascular sequelae,including myocarditis and heart failure,have also been reported.Here,the study presents two fulminant myocarditis cases infected by SARS-CoV-2 exhibiting remarkable elevation of cardiac biomarkers without significant pulmonary injury,as determined by imaging examina-tions.Immunohistochemical staining reveals the viral antigen within cardiomyocytes,indicating that SARS-CoV-2 could directly infect the myocardium.The full viral genomes from respiratory,anal,and myocardial specimens are obtained via next-generation sequencing.Phylogenetic analyses of the whole genome and spike gene indicate that viruses in the myocardium/pericardial effusion and anal swabs are closely related and cluster together yet diverge from those in the respiratory samples.In addition,unique mutations are found in the anal/myocardial strains compared to the respiratory strains,suggesting tissue-specific virus mutation and adaptation.These findings indicate genetically distinct SARS-CoV-2 variants have infiltrated and disseminated within myocardial tissues,independent of pulmonary injury,and point to different infection routes between the myocardium and respiratory tract,with myocardial infections potentially arising from intestinal infection.These findings highlight the potential for systemic SARS-CoV-2 infection and the importance of a thorough multi-organ assessment in patients for a comprehensive understanding of the pathogenesis of COVID-19.

Key words

COVID-19/SARS-CoV-2/Fulminant myocarditis/Myocardium/Infection

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基金项目

National Key R&D Program of China(2023YFC2307500)

National Key R&D Program of China(2021YFC2701700)

National Natural Science Foundation of China(82341115)

Beijing Research Center for Respiratory Infectious Diseases(BJRID2024-003)

Major Project of Guangzhou National Laboratory(GZNL2023A01001)

Major Project of Guangzhou National Laboratory(SRPG22-001)

National Science and Technology Infrastructure of China(National Pathogen Resource Center-NPRC-32)

Youth Innovation Promotion Association of CAS(Y2021034)

CAS Project for Young Scientists in Basic Research(YSBR-086)

Innovation Team and Talents Cultivation Program of the National Administration of Traditional Chinese Medicine(ZYYCXTD-D-202208)

出版年

2024
遗传学报
中国遗传学会 中国科学院遗传与发育生物学研究所

遗传学报

CSTPCD
影响因子：0.821
ISSN：1673-8527
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