首页|The transgenerational effects of maternal low-protein diet during lactation on offspring
The transgenerational effects of maternal low-protein diet during lactation on offspring
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Environmental factors such as diet and lifestyle can influence the health of both mothers and offspring.However,its transgenerational transmission and underlying mechanisms remain largely unknown.Here,using a maternal lactation-period low-protein diet(LPD)mouse model,we show that maternal LPD during lactation causes decreased survival and stunted growth,significantly reduces ovulation and litter size,and alters the gut microbiome in the female LPD-F1 offspring.The transcriptome of LPD-F1 metaphase Ⅱ(MⅡ)oocytes shows that differentially expressed genes are enriched in female pregnancy and multiple metabolic processes.Moreover,maternal LPD causes early stunted growth and impairs metabolic health,which is transmitted over two generations.The methylome alteration of LPD-F1 oocytes can be partly transmitted to the F2 oocytes.Together,our results reveal that LPD during lactation transgenerationally affects offspring health,probably via oocyte epigenetic changes.
State Key Laboratory of Stem Cell and Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China
University of Chinese Academy of Sciences,Beijing 100049,China
Institute of Laboratory Animal Sciences,CAMS & PUMC,Beijing 100021,China
Guangzhou Key Laboratory of Metabolic Diseases and Reproductive Health,Guangdong-Hong Kong Metabolism & Reproduction Joint Laboratory,Reproductive Medicine Center,Guangdong Second Provincial General Hospital,Guangzhou,Guangdong 510317,China
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Institute of Zoology and Guangdong Second Provincial General Hospital.This work was supported by the National R&D program ofScience and Technology Program of Guangzhou,ChinaScience and Technology Program of Guangzhou,ChinaNatural Science Foundation of Shandong ProvinceStrategic Collaborative Research Program of the Ferring Institute of Reproductive Medicine,Ferring Pharmaceuticals and Chine
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