首页|Whole-genome resequencing of Hu sheep identifies candidate genes associated with agronomic traits
Whole-genome resequencing of Hu sheep identifies candidate genes associated with agronomic traits
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The phenotypic diversity resulting from artificial or natural selection of sheep has made a significant contri-bution to human civilization.Hu sheep are a local sheep breed unique to China with high reproductive rates and rapid growth.Genomic selection signatures have been widely used to investigate the genetic mecha-nisms underlying phenotypic variation in livestock.Here,we conduct whole-genome sequencing of 207 Hu sheep and compare them with the wild ancestors of domestic sheep(Asiatic mouflon)to investigate the genetic characteristics and selection signatures of Hu sheep.Based on six signatures of selection ap-proaches,we detect genomic regions containing genes related to reproduction(BMPR1B,BMP2,PGFS,CYP19,CAMK4,GGT5,and GNAQ),vision(ALDH1A2,SAG,and PDE6B),nervous system(NAV1),and im-mune response(GPR35,SH2B2,PIK3R3,and HRAS).Association analysis with a population of 1299 Hu sheep reveals that those missense mutations in the GPR35(GPR35 g.952651 A＞G;GPR35 g.952496 C＞T)and NAV1(NAV1 g.84216190 C＞T;NAV1 g.84227412 G＞A)genes are significantly associated(P＜0.05)with immune and growth traits in Hu sheep,respectively.This research offers unique insights into the selection characteristics of Hu sheep and facilitates further genetic improvement and molecular investigations.
Hu sheepWhole-genome resequencingSelection signatureGPR35NAV1Single nucleotide polymorphism
State Key Laboratory of Herbage Improvement and Grassland Agro-Ecosystems,Key Laboratory of Grassland Livestock Industry Innovation,Ministry of Agriculture and Rural Affairs,Engineering Research Center of Grassland Industry,Ministry of Education,College of Pastoral Agriculture Science and Technology,Lanzhou University,Lanzhou,Gansu 730020,China
Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Lanzhou,Gansu 730046,China
College of Animal Science and Technology,Gansu Agricultural University,Lanzhou,Gansu 730070,China
National Key Research and Development Program of ChinaNational Key Research and Development Program of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of China
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