首页|microRNA-2184 orchestrates Mauthner-cell axon regeneration in zebrafish via syt3 modulation
microRNA-2184 orchestrates Mauthner-cell axon regeneration in zebrafish via syt3 modulation
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MicroRNAs(miRNAs)play a significant role in axon regeneration following spinal cord injury.However,the functions of numerous miRNAs in axon regeneration within the central nervous system(CNS)remain largely unexplored.Here,we elucidate the positive role of microRNA-2184(miR-2184)in axon regeneration within zebrafish Mauthner cells(M-cells).The upregulation of miR-2184 in a single M-cell can facilitate axon regeneration,while the specific sponge-induced silencing of miR-2184 leads to impeded regeneration.We show that syt3,a downstream target of miR-2184,negatively regulates axon regeneration,and the regeneration suppression modulated by syt3 depends on its binding to Ca2+.Furthermore,pharmaco-logical stimulation of the cAMP/PKA pathway suggests that changes in the readily releasable pool may affect axon regeneration.Our data indicate that miR-2184 promotes axon regeneration of M-cells within the CNS by modulating the downstream target syt3,providing valuable insights into potential therapeutic strategies.
Axon regenerationAxon ablationmiR-2184syt3Readily releasable pool
Xinghan Chen、Yueru Shen、Zheng Song、Xinliang Wang、Huaitong Yao、Yuan Cai、Zi-Ang Zhao、Bing Hu
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Hefei National Research Center for Physical Sciences at the Microscale,University of Science and Technology of China,Hefei,Anhui 230026,China
The First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei,Anhui 230026,China
Center for Advanced Interdisciplinary Science and Biomedicine of IHM,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei,Anhui 230026,China
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