Another piece of puzzle for the human microbiome:the gut virome under dietary modulation

Fengxiang Zhao ¹Jinfeng Wang¹

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作者信息

1. College of Food Science & Nutritional Engineering,China Agricultural University,Beijing 100083,China
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Abstract

The virome is the most abundant and highly variable microbial consortium in the gut.Because of difficulties in isolating and culturing gut viruses and the lack of reference genomes,the virome has remained a rela-tively elusive aspect of the human microbiome.In recent years,studies on the virome have accumulated growing evidence showing that the virome is diet-modulated and widely involved in regulating health.Here,we review the responses of the gut virome to dietary intake and the potential health implications,presenting changes in the gut viral community and preferences of viral members to particular diets.We further discuss how viral-bacterial interactions and phage lifestyle shifts shape the gut microbiota.We also discuss the specific functions conferred by diet on the gut virome and bacterial community in the context of horizontal gene transfer,as well as the import of new viral members along with the diet.Collating these studies will expand our understanding of the dietary regulation of the gut virome and inspire dietary in-terventions and health maintenance strategies targeting the gut microbiota.

Key words

Diet/Gut virome/Phage lifestyle/Auxiliary metabolic genes/Horizontal gene transfer

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基金项目

National Key Research and Development Program of China(2022YFA1304102)

National Natural Science Foundation of China(32070122)

National Natural Science Foundation of China(32370053)

National Natural Science Foundation of China(T2341010)

Chinese Universities Scientific Fund(2023RC022)

Pinduoduo-China Agricultural University Research Fund(PC2023B02015)

2115 Talent Development Program of China Agricultural University()

出版年

2024

遗传学报

中国遗传学会中国科学院遗传与发育生物学研究所

遗传学报

CSTPCD

影响因子：0.821

ISSN：1673-8527

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