Another piece of puzzle for the human microbiome:the gut virome under dietary modulation

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外文摘要：The virome is the most abundant and highly variable microbial consortium in the gut.Because of difficulties in isolating and culturing gut viruses and the lack of reference genomes,the virome has remained a rela-tively elusive aspect of the human microbiome.In recent years,studies on the virome have accumulated growing evidence showing that the virome is diet-modulated and widely involved in regulating health.Here,we review the responses of the gut virome to dietary intake and the potential health implications,presenting changes in the gut viral community and preferences of viral members to particular diets.We further discuss how viral-bacterial interactions and phage lifestyle shifts shape the gut microbiota.We also discuss the specific functions conferred by diet on the gut virome and bacterial community in the context of horizontal gene transfer,as well as the import of new viral members along with the diet.Collating these studies will expand our understanding of the dietary regulation of the gut virome and inspire dietary in-terventions and health maintenance strategies targeting the gut microbiota.

外文关键词：

DietGut viromePhage lifestyleAuxiliary metabolic genesHorizontal gene transfer

作者：

Fengxiang Zhao、Jinfeng Wang

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作者单位：

College of Food Science & Nutritional Engineering,China Agricultural University,Beijing 100083,China

基金：

National Key Research and Development Program of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaChinese Universities Scientific FundPinduoduo-China Agricultural University Research Fund2115 Talent Development Program of China Agricultural University

项目编号：

2022YFA13041023207012232370053T23410102023RC022PC2023B02015

出版年：

2024

DOI：

10.1016/j.jgg.2024.04.013

遗传学报

中国遗传学会中国科学院遗传与发育生物学研究所

遗传学报

CSTPCD

影响因子：0.821

ISSN：1673-8527

年,卷(期)：2024.51(10)