首页|The landscape and clinical relevance of intronic polyadenylation in human cancers

The landscape and clinical relevance of intronic polyadenylation in human cancers

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Intronic polyadenylation(IPA)is an RNA 3'end processing event which has been reported to play important roles in cancer development.However,the comprehensive landscape of IPA events across various cancer types is lacking.Here,we apply IPAFinder to identify and quantify IPA events in 10,383 samples covering all 33 cancer types from The Cancer Genome Atlas(TCGA)project.We identify a total of 21,835 IPA events,almost half of which are ubiquitously expressed.We identify 2761 unique dynamically changed IPA events across cancer types.Furthermore,we observe 8855 non-redundant clinically relevant IPA events,which could potentially be used as prognostic indicators.Our analysis also reveals that dynamic IPA usage within cancer signaling pathways may affect drug response.Finally,we develop a user-friendly data portal,IPACancer Atlas(http://www.tingni-lab.com/Pancan_IPA/),to search and explore IPAs in cancer.

Intronic polyadenylationCancerSingle nucleotide variantDrug sensitivityDatabase

Xiaomeng Cheng、Guanghui Jiang、Xiaolan Zhou、Jing Wang、Zhaozhao Zhao、Jiayu Zhang、Ting Ni

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State Key Laboratory of Genetic Engineering,National Clinical Research Center for Aging and Medicine,Huashan Hospital,Collaborative Innovation Center of Genetics and Development,Human Phenome Institute,Center for Evolutionary Biology,Shanghai Engineering Research Center of Industrial Microorganisms,School of Life Sciences,Fudan University,Shanghai 200438,China

MOE Key Laboratory of Contemporary Anthropology,School of Life Sciences,Fudan University,Shanghai 200438,China

State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock,Institutes of Biomedical Sciences,School of Life Sciences,Inner M

National Natural science Foundation of ChinaNational Natural science Foundation of ChinaNational Key Research and Development Program of ChinaNational Key Research and Development Program of China

92249302323705922023YFC36033002021YFA0909300

2024

10.1016/j.jgg.2024.04.014

遗传学报
中国遗传学会 中国科学院遗传与发育生物学研究所

遗传学报

CSTPCD
影响因子：0.821
ISSN：1673-8527
年,卷(期)：2024.51(10)