Bio-X Institutes,Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders,Ministry of Education,Shanghai Jiao Tong University,Shanghai 200240,China

Department of Statistics,George Washington University,Washington,DC 20052,USA

Department of Otorhinolaryngology Head and Neck Surgery,Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200233,China

Department of Ecology and Evolutionary Biology,University of Michigan,Ann Arbor,Ml 48109,USA