首页|Age-dependent genetic architectures of chicken body weight explored by multidimensional GWAS and moIQTL analyses

Age-dependent genetic architectures of chicken body weight explored by multidimensional GWAS and moIQTL analyses

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Chicken body weight(BW)is a critical trait in breeding.Although genetic variants associated with BW have been investigated by genome-wide association studies(GWAS),the contributions of causal variants and their molecular mechanisms remain largely unclear in chickens.In this study,we construct a compre-hensive genetic atlas of chicken BW by integrative analysis of 30 age points and 5 quantitative trait loci(QTL)across 27 tissues.We find that chicken growth is a cumulative non-linear process,which can be divided into three distinct stages.Our GWAS analysis reveals that BW-related genetic variations show ordered patterns in these three stages.Genetic variations in chromosome 1 may regulate the overall growth process,likely by modulating the hypothalamus-specific expression of SLC25A30 and retina-specific expression of NEK3.Moreover,genetic variations in chromosome 4 and chromosome 27 may play dominant roles in regulating BW during Stage 2(8-22 weeks)and Stage 3(23-72 weeks),respectively.In summary,our study presents a comprehensive genetic atlas regulating developmental stage-specific changes in chicken BW,thus providing important resources for genomic selection in breeding programs.

ChickenBody weightAge-dependentMolecular quantitative lociGWASFarmGTEx

Conghao Zhong、Xiaochang Li、Dailu Guan、The ChickenGTEx Consortium、Boxuan Zhang、Xiqiong Wang、Liang Qu、Huaijun Zhou、Lingzhao Fang、Congjiao Sun、Ning Yang

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State Key Laboratory of Animal Biotech Breeding and Frontier Science Center for Molecular Design Breeding,China Agricultural University,Beijing 100193,China

Department of Animal Science,University of California,Davis,CA 95616,USA

Jiangsu Institute of Poultry Science,Yangzhou,Jiangsu 225125,China

Center for Quantitative Genetics and Genomics(QGG),Aarhus University,Aarhus 8000,Denmark

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2024

10.1016/j.jgg.2024.09.003

遗传学报
中国遗传学会 中国科学院遗传与发育生物学研究所

遗传学报

CSTPCD
影响因子：0.821
ISSN：1673-8527
年,卷(期)：2024.51(12)