Objective:To extract the total flavonoids of Rhizoma fragrans by choline-low eutectic solvent.Methods:The nature of choline based low eutectic solvents(type,molar ratio of components,water content),extraction temperature,extraction time,liquid to material ratio and other factors were analyzed by the central combination design method.Results:It was found that the optimum extraction conditions for the total flavonoids of Cyperus Rotundus were:taking choline chloride as the hydrogen bond donor,propanetriol as the hydrogen bond acceptor,molar ratio 1∶2,20％water content,ratio 1∶4,30％water,extraction temperature 80 ℃,extraction time 40min,liquid-solid ratio 15mL/g.Conclusion:The present study suggests that choline-based low eutectic sol-vents can be applied as sustainable and efficient natural extraction media for the extraction of the pharmacodynamic components of Cyperus Rotundus.
关键词
胆碱类低共熔溶剂/香附总黄酮/中心组合设计
Key words
choline-low eutectic solvents/total flavonoids of Cyperus Rotundus/Center combination design
维普
万方数据