Case-control Study on Risk Factors for Children with RRTIs
Objective:To investigate the factors that were related with recurrent respiratory infections(RRTI)on-set in children and to analyze them by logistic regression analysis.Methods:The subjects of this study were recrui-ted from September 2016 to December 2017 at inpatient and outpatient of Xinhua Hospital,Yueyang Hospital,Shuguang Hospital and Jiading Hospital.Meanwhile,the healthy children who took routine medical examinations were randomly selected as the control group.A face-to-face interview survey was conducted to investigate the age,sex,and gestational age,birth weight,maternal gestational age,feeding style,family living environ-ment,diet preference and onset time of the disease.The risky factors were analyzed using univariable and multiva-riable logistic regression.Result:a total of 2157 cases were included in this study,including 1124 children with RRTI and 1033 healthy children.The composition ratio of 4-6 years old children with RRTI was the highest,and the most frequent RRTI-onset time was seasonal change.Univariable logistic regression showed that age,mater-nal age,gestational age,feeding practices,food partiality,the way and weight of birth were the influence factor for RRTI-onset.Multivariate logistic analysis showed that children 7-14 years old were at a threefold increased risk of RRTI than children 0-3 years old(OR 3.452,95％CI:2.219-5.370).Children with maternal age in-appropriate were at a twofold increased risk of RRTI than children with maternal age appropriate(OR 1.964,95％CI:1.560-2.473).Children with caesarean section were at a twofold increased risk of RRTI than children with eutocia(OR 2.238,95％CI:1.778-2.818).Premature infant were at a twofold increased risk of RRTI than normal term infant(OR 2.387,95％CI:1.067-5.340).Children with low birth weight were at a three-fold increased risk of RRTI than children with normal birth weight(OR 3.114,95％CI:1.097-8.842).The risks of RRTI in children with breast feeding and partial breastfeeding were declined almost 40％(OR 0.362,95％CI:0.250-0.526)and 20％(OR 0.247,95％CI:1.067-5.340),respectively,compared to children with milk feeding.Children who prefer spicy food were at a seven fold increased risk of RRTI than children without food partiality(OR 7.023,95％CI:2.400-20.549).Children who prefer sweetmeat and meat were at a threefold increased risk of RRTI than children without food partiality(OR 2.635,95％CI:1.843-3.768 and OR 2.912,95％CI:1.967-4.311,respectively).Conclusion:Low birth weight,small for gestational age,caesarean sec-tion,non-breast-feeding,children age at 7-14 years old,seasonal change and food partiality were related with RRTI-onset.Hence,parents should pay more attention to treatment and protection of their children with a-bove risky factors who suffering from respiratory tract infections,which avoid to trigger RRTI-onset.
万方数据
维普
