Petroleum ether,dichloromethane,ethyl acetate,ethanol and water were used to prepare Boenning-hausenia sessilicarpa(B.sessilicarpa)crude extracts by ultrasonically enhanced extraction,respectively.The an-ti-inflammatory active extracts were confirmed based on the experiment in auricle swelling induced by xylol in mice,and characterized by mass spectrometry(MS).The results showed that all the five crude extracts eased auricle swelling induced by xylol in mice.Ethanol crude extracts and water crude extracts had statistical differences in swelling inhibition compared to the model control group,which were the effective anti-inflammatory fraction of B.sessilicarpa.Ethanol crude extracts had characteristic ion signal peaks of m/z 103.99、259.97、274.11、318.14、593.17 in the mass spectrometry.Water crude extracts had characteristic ion signal peaks of m/z 103.99、274.11、318.14、453.16、701.38 in the mass spectrometry.