Applications of Cells and Organoids Differentiated from hiPSCs in the Study of SARS-CoV-2 Infection
SARS-CoV-2 has caused a global pandemic of COVID-19,and the study of SARS-CoV-2 infec-tion is of great significance for the understanding of pathological reaction of human cells and organs that are infec-ted by the viruses.After airways,lung organoids,nervous system cells,brain organoids,cardiomyocytes,blood vessels,intestinal organoids and kidney organoids were differentiated from hiPSCs,they were applied in SARS-CoV-2 infection study.It was found that after the cells and organoids were infected by SARS CoV-2,their physiological activity was damaged and physiological functions were impaired.Secretion of inflammatory cyto-kines increased,causing inflammatory reaction and functional deterioration of the organoids.Therefore,the cells and organoids that are differentiated from hiPSCs can be used for SARS-CoV-2 infection study,and the viral infection affects the functions of the cells and organoids.
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