Research Progress on Salivary Biomarkers for the Diagnosis of Parkinson's Disease
Parkinson's disease(PD)is the second most common neurodegenerative disease.PD has an insidious onset,and there is currently no effective cure for it in clinical practice.Early diagnosis of PD is necessary to begin treatment before the onset of obvious clinical symptoms,so as to slow down the progression of the disease,a-chieve better treatment effects,and improve the quality of life of patients.In recent years,due to the advantages of non-invasive and inexpensive methods of saliva collection,saliva has gained more attention as a source of bio-markers for the diagnosis of diseases.This review aims to provide an insight into the research progress on salivary biomarkers used in the diagnosis of PD,such as α-synuclein,DJ-1,HO-1 and AChE.Among them,the re-search on α-synuclein is the most intensive and has yielded relatively consistent results,indicating that salivary α-synuclein has the potential to become a diagnostic biomarker for PD.
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