Regional Homogeneity Study of Resting State Functional Magnetic Resonance in Patients with Postural Instability/Gait Disorder Parkinson's Disease
Objective:To investigate the changes of spontaneous neuronal activity in the brain of postural instabili-ty/gait disorder(PIGD)subtype of Parkinson's disease(PD)and its clinical significance by using the Regional homogeneity(ReHo)analysis method of resting state functional MRI.Methods:A total of 24 patients with PIGD subtype PD and 23 healthy controls were recruited from April 2020 to June 2022.The whole brain resting state functional MRI data of the two groups were collected.After data preprocessing,the ReHo value was calculated and the difference between the groups was statistically compared.Finally,the correlation analysis and comparison were conducted between the ReHo values that extracted from the PD patients with significant changes in brain are-as and clinical parameters.Results:Compared with the healthy control group,the ReHo of the left temporal pole,right insula and left superior temporal gyrus were increased in PIGD PD patients.Decreased ReHo in the right cun-eus,right medial frontal gyrus,left middle occipital gyrus,right superior temporal gyrus,left anterior cuneus,right anterior cingulate gyrus,right anterior central gyrus,and left posterior central gyrus(P＜0.001,multiple comparison correction).The ReHo value of the right insular lobe was negatively correlated with UPDRS-Ⅱ,UPDRS-Ⅲ,PIGD score and axial symptoms(P values were 0.046,0.049,0.024,0.024,respectively).Conclusion:There are specific spontaneous brain activity changes in patients with PIGD subtype PD,which are mainly located in cortical-striatal circuit,prominence network and visual network.It provides a new understand-ing of the pathophysiological mechanism of PIGD subtype PD patients.
Parkinson's diseaseFunctional magnetic resonance imagingPostural instability/gait disturbanceRegional homogeneity
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