Study on the Therapeutic Effect of Qingkailing Granules on Pulmonary Inflammatory Response and Injury in Mice with Heatstroke
Objective:Study the therapeutic effect of Qingkailing granules on heatstroke in mice.Methods:Estab-lish a mouse model of heat stroke,and detect changes in indicators such as lymphocytes,neutrophils,red blood cell accumulation,hemoglobin,and platelets in heat stroke mice before and after drug treatment using blood rou-tine tests.TUNEL staining and immunohistochemistry were used to detect the apoptosis of lung tissue in each group of mice.Hematoxylin and eosin staining were used to observe the pathological changes in the alveoli of mice treated with various drugs.Results:Research has shown that after treatment with Qingkailing,the lymphocyte ratio,neutrophil ratio,hemoglobin and other indicators of experimental mice returned to normal range,and the degree of inflammatory cell infiltration and apoptosis rate in lung tissue decreased.The expression of apoptosis fac-tor caspase in lung tissue was significantly reduced after treatment with medium and high doses of Qingkailing,and there was a significant difference.Conclusion:Qingkailing granules can effectively treat lung inflammation and injury caused by heatstroke.It has the prospect of being developed as anti-heatstroke drug.
万方数据
维普
