Study on the Relationship between Stair Climbing Exercise and the Risk of Non-small Cell Lung Cancer
This article using Mendelian randomization(MR)method to analyze the causal relationship between stair climbing frequency and the risk of lung cancer.Collect genome-wide association study(GWAS)data on stair climbing frequency,lung cancer,small cell lung cancer,non-small cell lung cancer,squamous cell carcinoma,and lung adenocarcinoma.Use stair climbing frequency as an exposure factor to screen for significantly correlated single nucleotide polymorphism sites(SNPs)as instrumental variables,and different types of lung cancer as outcome variables.Evaluate the association between stair climbing frequency and different types of lung cancer using inverse variance weighting(IVW),weighted median(WM),and maximum likelihood(ML)methods.Research has found a negative correlation between stair climbing frequency and lung cancer.The frequency of climbing stairs is negatively correlated with non-small cell lung cancer.The frequency of climbing stairs is negatively correlated with squamous cell carcinoma.The frequency of climbing stairs is negatively correlated with lung adenocarcinoma.From this,it can be concluded that increasing the frequency of climbing stairs in daily life can effectively reduce the risk of non-small cell lung cancer,and this result still needs further verification.
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