Fasteners are the most widely used basic products in aerospace models,the connecting designing technology of which could affect the reliability of aerospace models.Seizure is the most common failure mode of aerospace fasteners,once seizure,the rocket assemble process and even the launch mission will be severely adversely affected.Based on the surface and interface thermo-dynamic analysis of screw pairs,simulation analysis under different friction coefficients,friction and wear tests under different matching states,observation and chemical analysis of surface and interface after wear experiment and so on,the main factors causing aerospace fasteners seizure will be investigated.Meanwhile,the impact pattern could be deeply analyzed and the mechanism could be systematically summarized.The research results of this article aim to improve the seizure phe-nomenon and enhance the reliability of fastening connecting in aerospace models,thus,required theoretical basis and technical support will be provided.