The lightweight design of structure is of great significance in aerospace engineering.The combination of additive manufacturing and lattice structure is an important way to realize the light-weight of spacecraft structure.In this study,a novel design method of lattice-infilled structure for additive manufacturing is proposed.The weight reduction of the structure is achieved by topology optimization and lattice filling under the condition of ensuring the structural stiffness,and the oc-tree refinement based on the lattice cell of shell boundary position is proposed to realize the self-supporting of lattice-infill structure.The proposed design method is used to carry out the light-weight design research on the beam structure of spacecraft inertial navigation unit,and the weight reduction of the structure is more than 40%.The novel self-lattice-infill beam structure was fabri-cated by additive manufacturing.The numerical analysis and experimental results show that the lattice-infill structure shows better stiffness characteristics than the conventional beam structure.The design method proposed in this study provides a new technical approach for lightweight design of spacecraft structures.