THE PROTECTIVE EFFECTS OF POLYPHENOLS FROM PINUS KORAIENSIS AND POLYSACCHARIDES FROM AURICULARIAE AURICULAE ON ANTIOXIDANT FUNCTION IN RADIATION INJURED MICE
Objective To study the effects of polysaccharides from A uriculariae auriculae (AAP) and combinations of AAP and polyphenols from Pinus koraiensis (AAP/PKP) on antioxidant function in 60Co gamma radiation injured mice.Methods AAP was given to mice by gavage at three different doses of 50,100 and 200 mg/(kg·d).AAP/PKP was given to mice by gavage at three different doses of 50+30,100+60 and 200+120 mg/(kg·d).The control and model groups were given normal saline by gavage.After 30 days,the model group and six AAP and AAP/PKP experimental groups were irradiated once with 60Co gamma ray.The total absorbed dose was 6.0 Gy,and the absorbed dose rate was 1.0 Gy/min.The contents of vitamin C (VC),vitamin E (VE),glutathione (GSH),coenzyme Q10 (CoQl0),malondialdehyde (MDA) and activity of superoxide dismutase (SOD),glutathione peroxidase (gsh-px) and catalase (CAT) in the serum,spleen,liver,heart,kidney,and brain of mice were determined.Results It showed that the AAP,AAP/PKP at the high dose group could significantly increase the content of VC,VE,GSH,CoQ10,and improve the activity of SOD,GSH-Px and CAT,while MDA content was reducd compared to the model group.Conclusion Compared to AAP,AAP/PKP can more effectively scavenge free radicals,and more significantly improve antioxidant function in radiation treated mice.
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NSTL
万方数据
维普
