ASSOCIATIONS BETWEEN SERUM 25-HYDROXYVITAMIN D3 LEVEL AND THE PREVALENCES OF DIABETES AND ABNORMAL BLOOD GLUCOSE IN A CHINESE ADULT POPULATION
Objective To explore the associations between serum vitamin D(VD)level and the prevalences of diabetes/abnormal blood glucose in a Chinese population.Methods A total of 2072 eligible subjects over 18 years of age were included by the multi-stage sampling method.Serum 25 hydroxyvitamin D3(25(OH)D3)level and lipid metabolism indexes were detected,and relevant demographic and physical information were collected.Multiple logistic regression analysis was used to examine the relationship between serum 25(OH)D3 level and the prevalences of diabetes and abnormal blood glucose.Results The prevalence of diabetes was 5.69%,the rate of abnormal blood glucose was 54.68%,and the rate of vitamin D deficiency was 19.79%.The rate of vitamin D deficiency was 28.81%in diabetic subjects and 19.59%in abnormal blood glucose subjects.The prevalence of diabetes in subjects with vitamin D deficiency was significantly higher than that in subjects with vitamin D sufficiency(8.25%vs 5.06%,P=0.012),while there was no statistically significant difference in the rates of abnormal blood glucose between the subjects with vitamin D deficiency and vitamin D sufficiency(20.83%vs 19.59%,P=0.716).After adjusting for multiple factors such as age,region,exercise,BMI,fasting lipids,and blood pressure,the decrease of serum 25(OH)D3 level was associated with a higher prevalence of diabetes(P=0.046),and the risk of diabetes/abnormal blood glucose was increased by 1.391(1.039-1.861)times for every 10 ng/ml decrease in serum 25(OH)D3 level(P=0.026).After further stratification of the diabetic subjects,compared with the vitamin D adequate group,the risk of diabetes in the vitamin D deficiency group was 1.594(1.009-2.520,P=0.046)after multi-factor adjustment.The risk of diabetes was increased by 1.391(1.039-1.861)times for every 10 ng/ml decrease in serum vitamin D3 level(P=0.026).Conclusion Vitamin D deficiency may be an independent risk factor for high incidence of diabetes in Chinese adult population.[ACTA NUTRIMENTA SINICA,2024,46(2):132-138,145]
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