目的 综述母乳维生素 D水平,为婴儿补充维生素 D提供参考.方法 系统检索 CNKI、万方、维普、中国生物医学文献数据库、PubMed、Web of Science、Embase、Cochrane library中英文数据库,收集 2022 年 4 月之前公开发表的母乳维生素 D 水平的相关文献.将维生素 D 质量单位统一后,根据均数和标准差合并公式,计算国内外不同亚组母乳维生素D含量.结果 最终纳入 14 篇报告了足月分娩健康母亲母乳维生素D含量的原始文献,其中中国人群 3 篇,国外人群 11 篇.结果 显示,中国足月分娩健康母亲初乳、过渡乳、成熟乳中维生素 D含量(μg/L)分别为(0.801±0.342)、(25.132±30.540)、(3.792±0.614).国外足月分娩健康母亲初乳、过渡乳、成熟乳中维生素D含量(μg/L)分别为(25.191±15.845)、(1.045±1.740)、(0.943±2.034).结论 国内外母乳维生素D水平差异较大,且受多种因素影响.未来需要更大样本量的研究,了解母乳维生素D含量及影响因素.
THE LEVEL OF VITAMIN D IN BREAST MILK AND ITS INFLUENCING FACTORS:A SYSTEMATIC REVIEW
Objective To assess the level of vitamin D in breast milk and provide evidence for vitamin D supplementation in the infants.Methods We searched for relevant studies published up to April 2022 from CNKI,Wanfang,VIP,CB-Mdisc,PubMed,Web of Science,Embase,and Cochrane library.After unifying the unit of vitamin D,we calculated the level of vitamin D in breast milk among the participants in different subgroups in China and abroad according to statistical formulas.Results A total of 14 articles were included in this study,including 3 articles performed in China and 11 articles performed in other countries.Our study showed that the levels of vitamin D in breast milk among Chinese healthy mothers with term infants in colostrum,transitional,and mature milk were(0.801±0.342)μg/L,(25.132±30.540)μg/L,and(3.792±0.614)μg/L,respectively.The levels of vitamin D in breast milk among foreign healthy mothers with term infants in colostrum,transitional,and mature milk were(25.191±15.845)μg/L,(1.045±1.740)μg/L,and(0.943±2.034)μg/L,respectively.Conclusion The level of vitamin D in breast milk in China was very different from that in other countries,which was influenced by numerous factors.Studies with larger sample sizes are needed to investigate the level of vitamin D in breast milk and its influencing factors.
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万方数据
