EFFECT OF PROBIOITIC SUPPLEMENTATION ON DEPRESSION STATUS IN PREGNANT WOMEN AT HIGH RISK OF GESTATIONAL DIABETES MELLITUS
Objective To observe the effect of probiotics on the depression status in pregnant women at high risk of gestational diabetes mellitus(GDM),and to provide new ideas for improving the depression status.Methods A total of 446 pregnant women with high risk factors of GDM in Nanjing Maternal and Child Health Hospital from June 2020 to June 2021 were randomly divided into probiotics group(n=223)and placebo control group(n=223).From the first trimester(within 15 weeks)to the third trimester until delivery,one sachet of probiotics or placebo was administered per day.The depression status of the high-risk GDM groups with in the second trimester(24-28 weeks)and third trimester(34-36 weeks)at the time of enrollment(within 15 weeks)was evaluated through questionnaire and the depression self-rating scale.Results After 22 weeks of intervention,the depression status of the probiotic group was significantly improved compared with that of the control group(P<0.05).Compared with before the intervention,the depression status of the depressed pregnant women in the high risk GDM group decreased significantly after 12 and 22 weeks of intervention(P<0.01).Conclusion The depression status of the pregnant women at high risk of GDM can be improved by supplementing probiotics.[ACTA NUTRIMENTA SINICA,2024,46(4):328-333]
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