补充益生菌对妊娠期糖尿病高危孕妇抑郁状况的影响
EFFECT OF PROBIOITIC SUPPLEMENTATION ON DEPRESSION STATUS IN PREGNANT WOMEN AT HIGH RISK OF GESTATIONAL DIABETES MELLITUS
王金晶 1孙霁寒 1苗苗 2戴永梅 2王煚楠 1孙桂菊1
作者信息
- 1. 东南大学公共卫生学院环境医学工程教育部重点实验室/营养与食品卫生学系,南京 210009
- 2. 南京市妇幼保健院,南京 210004
- 折叠
摘要
目的 观察益生菌对妊娠期糖尿病高危孕妇抑郁状况的影响,为妊娠期糖尿病高危孕妇抑郁状况改善提供新思路.方法 选择 2020 年 6 月至 2021 年 6 月就诊于南京市妇幼保健院具有妊娠期糖尿病高危因素的 446 例孕早期(15 w内)孕妇作为研究对象,随机分为益生菌组和安慰剂对照组各 223 例.从孕早期(15 w内)持续干预至孕晚期,每日服用益生菌或安慰剂一袋.通过基本情况调查问卷、抑郁自评量表采集入组时(15 w内),孕中期(24～28 w)和孕晚期(34～36 w)妊娠期糖尿病高危孕妇的抑郁状况.结果 干预 22 w后,益生菌组抑郁状况改善,和对照组相比有统计学差异(P＜0.05);与干预前相比,存在抑郁状况的妊娠期糖尿病高危孕妇在孕中期和孕晚期的抑郁状况均显著性下降(P＜0.01).结论 通过补充益生菌可以改善妊娠期糖尿病高危孕妇的抑郁状况.[营养学报,2024,46(4):328-333]
Abstract
Objective To observe the effect of probiotics on the depression status in pregnant women at high risk of gestational diabetes mellitus(GDM),and to provide new ideas for improving the depression status.Methods A total of 446 pregnant women with high risk factors of GDM in Nanjing Maternal and Child Health Hospital from June 2020 to June 2021 were randomly divided into probiotics group(n=223)and placebo control group(n=223).From the first trimester(within 15 weeks)to the third trimester until delivery,one sachet of probiotics or placebo was administered per day.The depression status of the high-risk GDM groups with in the second trimester(24-28 weeks)and third trimester(34-36 weeks)at the time of enrollment(within 15 weeks)was evaluated through questionnaire and the depression self-rating scale.Results After 22 weeks of intervention,the depression status of the probiotic group was significantly improved compared with that of the control group(P<0.05).Compared with before the intervention,the depression status of the depressed pregnant women in the high risk GDM group decreased significantly after 12 and 22 weeks of intervention(P<0.01).Conclusion The depression status of the pregnant women at high risk of GDM can be improved by supplementing probiotics.[ACTA NUTRIMENTA SINICA,2024,46(4):328-333]
关键词
益生菌/抑郁/妊娠期糖尿病高危孕妇Key words
probiotics/depression/high GDM risk pregnant women引用本文复制引用
基金项目
江苏省研究生科研与实践创新项目(SJCX21_0088)
出版年
2024
NETL
NSTL
万方数据