Objective To observe the effect of probiotics on the depression status in pregnant women at high risk of gestational diabetes mellitus(GDM),and to provide new ideas for improving the depression status.Methods A total of 446 pregnant women with high risk factors of GDM in Nanjing Maternal and Child Health Hospital from June 2020 to June 2021 were randomly divided into probiotics group(n=223)and placebo control group(n=223).From the first trimester(within 15 weeks)to the third trimester until delivery,one sachet of probiotics or placebo was administered per day.The depression status of the high-risk GDM groups with in the second trimester(24-28 weeks)and third trimester(34-36 weeks)at the time of enrollment(within 15 weeks)was evaluated through questionnaire and the depression self-rating scale.Results After 22 weeks of intervention,the depression status of the probiotic group was significantly improved compared with that of the control group(P<0.05).Compared with before the intervention,the depression status of the depressed pregnant women in the high risk GDM group decreased significantly after 12 and 22 weeks of intervention(P<0.01).Conclusion The depression status of the pregnant women at high risk of GDM can be improved by supplementing probiotics.[ACTA NUTRIMENTA SINICA,2024,46(4):328-333]
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