首页|Phosphorylation Promotes the Accumulation of PERIOD Protein Foci
Phosphorylation Promotes the Accumulation of PERIOD Protein Foci
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Circadian clock drives the 24-h rhythm in our behavior and physiology.The molecular clock consists of a series of transcriptional/translational feedback loops operated by a number of clock genes.A very recent study reported that the clock protein PERIOD(PER)is organized into discrete foci at the nuclear envelope in fly circadian neurons,which is believed to be important for controlling the subcellular localization of clock genes.Loss of inner nuclear membrane protein lamin B receptor(LBR)leads to disruption of these foci,but how they are regulated is yet unknown.Here,we found that PER foci are likely phase-separated condensates,the formation of which is mediated by intrinsically disordered region in PER.Phosphorylation promotes the accumulation of these foci.Protein phosphatase 2A,which is known to dephosphorylate PER,hampers the accumulation of the foci.On the other hand,the circadian kinase DOUBLETIME(DBT)which phosphorylates PER enhances the accumulation of the foci.LBR likely facilitates PER foci accumulation by destabilizing the catalytic subunit of protein phosphatase 2A,MICROTUBULE STAR(MTS).In conclusion,here,we demonstrate a key role for phosphorylation in promoting the accumulation of PER foci,while LBR modulates this process by impinging on the circadian phosphatase MTS.
Mengna Li、Shujing Li、Luoying Zhang
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Key Laboratory of Molecular Biophysics of Ministry of Education,College of Life Science and Technology,Huazhong University of Science and Technology,Wuhan,Hubei 430074,China
Department of Life Sciences,Bengbu Medical College,Bengbu,Anhui 233030,China
Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration,Wuhan,Hubei 430022,China
国家自然科学基金国家自然科学基金Ministry of Science and Technology of China STI 2030-Major Projects
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