首页|Living Chinese Herbal Scaffolds from Microfluidic Bioprinting for Wound Healing

Living Chinese Herbal Scaffolds from Microfluidic Bioprinting for Wound Healing

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Biological scaffolds have been widely employed in wound healing applications,while their practical efficiency is compromised by insufficient oxygen delivery to the 3-dimensional constructs and inadequate nutrient supply for the long-term healing process.Here,we present an innovative living Chinese herbal scaffold to provide a sustainable oxygen and nutrient supply for promoting wound healing.Through a facile microfluidic bioprinting strategy,a traditional Chinese herbal medicine(Panax notoginseng saponins[PNS])and a living autotrophic microorganism(microalgae Chlorella pyrenoidosa[MA])were successfully encapsulated into the scaffolds.The encapsulated PNS could be gradually released from the scaffolds,which promoted cell adhesion,proliferation,migration,and tube formation in vitro.In addition,benefiting from the photosynthetic oxygenation of the alive MA,the obtained scaffolds would produce sustainable oxygen under light illumination,exerting a protective effect against hypoxia-induced cell death.Based on these features,we have demonstrated through in vivo experiments that these living Chinese herbal scaffolds could efficiently alleviate local hypoxia,enhance angiogenesis,and thereby accelerate wound closure in diabetic mice,indicating their great potential in wound healing and other tissue repair applications.

Xiaocheng Wang、Jinxuan Jia、Mengying Niu、Wenzhao Li、Yuanjin Zhao

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Department of Rheumatology and Immunology,Nanjing Drum Tower Hospital,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210096,China

Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine,Vision and Brain Health),Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou,Zhejiang 325001,China

State Key Laboratory of Bioelectronics,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210096,China

Chemistry and Biomedicine Innovation Cen

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国家重点研发计划国家自然科学基金国家自然科学基金Guangdong Basic and Applied Basic Research FoundationShenzhen Fundamental Research ProgramFellowship of China Postdoctoral Science Foundation

2020YFA090820032201117520730602021B1515120054JCYJ201908131526164592021M700141

2024

10.34133/research.0138

研究(英文)

研究(英文)

CSTPCD
ISSN：
年,卷(期)：2024.2024(1)
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