首页|Traditional Chinese Medicine Integrated Responsive Microneedles for Systemic Sclerosis Treatment

Traditional Chinese Medicine Integrated Responsive Microneedles for Systemic Sclerosis Treatment

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Traditional Chinese medicine,such as Tripterygium wilfordii and Paeonia lactiflora,has potential values in treating systemic sclerosis(SSc)and other autoimmune diseases,while their toxic side effect elimination and precise tropical drug delivery are still challenges.Here,we present multiple traditional Chinese medicine integrated photoresponsive black phosphorus(BP)microneedles(MNs)with the desired features for the SSc treatment.By employing a template-assisted layer-by-layer curing method,such MNs with triptolide(TP)/paeoniflorin(Pae)needle tips and BP-hydrogel needle bottoms could be well generated.The combined administration of TP and Pae can not only provide anti-inflammatory,detoxification,and immunomodulatory effects to treat skin lesions in the early stage of SSc but also remarkably reduce the toxicity of single drug delivery.Besides,the additive BPs possess good biocompatibility and near-infrared(NIR)responsiveness,imparting the MN photothermal-controlled drug release capability.Based on these features,we have demonstrated that the traditional Chinese medicine integrated responsive MNs could effectively improve skin fibrosis and telangiectasia,reduce collagen deposition,and reduce epidermal thickness in the SSc mouse models.These results indicated that the proposed Chinese medicine integrated responsive MNs had enormous potential in clinical therapy of SSc and other diseases.

Xi Luan、Xiaoxuan Zhang、Min Nie、Yuanjin Zhao

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Department of Rheumatology and Immunology,Nanjing Drum Tower Hospital,School of Pharmacy,Clinical College of Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing 210023,China

State Key Laboratory of Bioelectronics,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210096,China

国家重点研发计划国家自然科学基金国家自然科学基金国家自然科学基金Nanjing Medical Science and Technique Development FoundationClinical Trials from Nanjing Drum Tower HospitalGuangdong Basic and Applied Basic Research FoundationShenzhen Fundamental Research ProgramShenzhen Fundamental Research ProgramPostgraduate Research & Practice Innovation Program of Jiangsu Province

2020YFA0908200T22250035207306061927805ZKX210192022-LCYJ-ZD-012021B1515120054JCYJ20190813152616459JCYJ20210324133214038KYCX22_2064

2024

10.34133/research.0141

研究(英文)

研究(英文)

CSTPCD
ISSN：
年,卷(期)：2024.2024(1)
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