首页|Body-Shaping Membrane to Regenerate Breast Fat by Elastic Structural Holding

Body-Shaping Membrane to Regenerate Breast Fat by Elastic Structural Holding

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Tissue regeneration requires structural holding and movement support using tissue-type-specific aids such as bone casts,skin bandages,and joint protectors.Currently,an unmet need exists in aiding breast fat regeneration as the breast moves following continuous body motion by exposing the breast fat to dynamic stresses.Here,the concept of elastic structural holding is applied to develop a shape-fitting moldable membrane for breast fat regeneration("adipoconductive")after surgical defects are made.The membrane has the following key characteristics:(a)It contains a panel of honeycomb structures,thereby efficiently handling motion stress through the entire membrane;(b)a strut is added into each honeycomb in a direction perpendicular to gravity,thereby suppressing the deformation and stress concentration upon lying and standing;and(c)thermo-responsive moldable elastomers are used to support structural holding by suppressing large deviations of movement that occur sporadically.The elastomer became moldable upon a temperature shift above Tm.The structure can then be fixed as the temperature decreases.As a result,the membrane promotes adipogenesis by activating mechanotransduction in a fat miniature model with pre-adipocyte spheroids under continuous shaking in vitro and in a subcutaneous implant placed on the motion-prone back areas of rodents in vivo.

Hye-Seon Kim、Jeongeun Park、Hyun-Su Ha、Sewoom Baek、Chan Hee Lee、Kyubae Lee、Suji Park、Jueun Kim、Se Won Yi、Hak-Joon Sung

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Department of Medical Engineering,Graduate School of Medical Science,Brain Korea 21 Project,Yonsei University College of Medicine,Seoul 03722,Republic of Korea

TMD LAB Co.Ltd.,6th Floor,31,Gwangnaru-ro 8-gil,Seongdong-gu,Seoul 04799,Republic of Korea

Korea Medical Device Development FundMinistry of Science and ICT,the Ministry of Trade,Industry and Energy,the Ministry of Health & Welfare,the Ministry of Food Ministry of Science and ICT,the Ministry of Trade,Industry and Energy,the Ministry of Health & Welfare,the Ministry of Food National Research Foundation of Korea(NRF)funded by the Korean government(MSIT)National Research Foundation of Korea(NRF)funded by the Korean government(MSIT)Brain Korea 21 PLUS Project for Medical Science of Yonsei UniversityMD-PhD/Medical Scientist Training Program through the Korea Health Industry Development Institute(KHIDI)Ministry of Health and Welfare

1711138302KMDF_PR_20200901_0152-012019R1A2C20108022021R1A6A3 A13044778

2024

10.34133/research.0137

研究(英文)

研究(英文)

CSTPCD
ISSN：
年,卷(期)：2024.2024(1)
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