首页|Bioinspired Hemostatic Strategy via Pulse Ejections for Severe Bleeding Wounds

Bioinspired Hemostatic Strategy via Pulse Ejections for Severe Bleeding Wounds

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Efficient hemostasis during emergency trauma with massive bleeding remains a critical challenge in prehospital settings.Thus,multiple hemostatic strategies are critical for treating large bleeding wounds.In this study,inspired by bombardier beetles to eject toxic spray for defense,a shape-memory aerogel with an aligned microchannel structure was proposed,employing thrombin-carrying microparticles loaded as a built-in engine to generate pulse ejections for enhanced drug permeation.Bioinspired aerogels,after contact with blood,can rapidly expand inside the wound,offering robust physical barrier blocking,sealing the bleeding wound,and generating a spontaneous local chemical reaction causing an explosive-like generation of C02 microbubbles,which provide propulsion thrust to accelerate burst ejection from arrays of microchannels for deeper and faster drug diffusion.The ejection behavior,drug release kinetics,and permeation capacity were evaluated using a theoretical model and experimentally demonstrated.This novel aerogel showed remarkable hemostatic performance in severely bleeding wounds in a swine model and demonstrated good degradability and biocompatibility,displaying great potential for clinical application in humans.

Bitao Lu、Enling Hu、Weiwei Ding、Wenyi Wang、Ruiqi Xie、Kun Yu、Fei Lu、Guangqian Lan、Fangyin Dai

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State Key Laboratory of Silkworm Genome Biology,College of Sericulture,Textile and Biomass Sciences,Southwest University,Chongqing 400715,China

Chongqing Engineering Research Center of Biomaterial Fiber and Modern Textile,Chongqing 400715,China

Division of Trauma and Surgical Intensive Care Unit,Research Institute of General Surgery,Jinling Hospital,Medical School of Nanjing University,Nanjing,210002 Jiangsu Province,China

Department of Applied Biology and Chemical Technology,The Hong Kong Polytechnic University,Hong Kong,China

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China Agriculture Research SystemInnovation Research 2035 Pilot Plan of Southwest University国家自然科学基金Innovation Project for Graduate Students of Chongqing

CARS-18-ZJ0102SWU-XDPY2201081703424CYB21121

2024

10.34133/research.0150

研究(英文)

研究(英文)

CSTPCD
ISSN：
年,卷(期)：2024.2024(1)
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