首页|Advanced Strategies for Overcoming Endosomal/Lysosomal Barrier in Nanodrug Delivery

Advanced Strategies for Overcoming Endosomal/Lysosomal Barrier in Nanodrug Delivery

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Nanocarriers have therapeutic potential to facilitate drug delivery,including biological agents,small-molecule drugs,and nucleic acids.However,their efficiency is limited by several factors;among which,endosomal/lysosomal degradation after endocytosis is the most important.This review summarizes advanced strategies for overcoming endosomal/lysosomal barriers to efficient nanodrug delivery based on the perspective of cellular uptake and intracellular transport mechanisms.These strategies include promoting endosomal/lysosomal escape,using non-endocytic methods of delivery to directly cross the cell membrane to evade endosomes/lysosomes and making a detour pathway to evade endosomes/lysosomes.On the basis of the findings of this review,we proposed several promising strategies for overcoming endosomal/lysosomal barriers through the smarter and more efficient design of nanodrug delivery systems for future clinical applications.

Chong Qiu、Fei Xia、Junzhe Zhang、Qiaoli Shi、Yuqing Meng、Chen Wang、Huanhuan Pang、Liwei Gu、Chengchao Xu、Qiuyan Guo、Jigang Wang

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Artemisinin Research Center,and Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China

Department of Nephrology,and Shenzhen Clinical Research Centre for Geriatrics,Shenzhen People's Hospital,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,Guangdong 518020,China

Fundamental Research Funds for the National Natural Science FoundationFundamental Research Funds for the National Natural Science FoundationCentral Public Welfare Research InstitutesCentral Public Welfare Research InstitutesCentral Public Welfare Research InstitutesCentral Public Welfare Research InstitutesCentral Public Welfare Research InstitutesCentral Public Welfare Research InstitutesCentral Public Welfare Research InstitutesCentral Public Welfare Research InstitutesYoung Elite Scientists Sponsorship Program by CACM

8220432282104480ZZ16-ND-10-05ZZ16-ND-10-13ZZ16-ND-10-17ZZ16-ND-10-19ZZ14-YQ-050ZZ14-YQ-055ZZ14-YQ-059ZZ14-YQ-2021QNRC2B29

2024

10.34133/research.0148

研究(英文)

研究(英文)

CSTPCD
ISSN：
年,卷(期)：2024.2024(1)
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