首页|Cardiac-Adaptive Conductive Hydrogel Patch Enabling Construction of Mechanical-Electrical Anisotropic Microenvironment for Heart Repair
Cardiac-Adaptive Conductive Hydrogel Patch Enabling Construction of Mechanical-Electrical Anisotropic Microenvironment for Heart Repair
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The biomimetic construction of a microstructural-mechanical-electrical anisotropic microenvironment adaptive to the native cardiac tissue is essential to repair myocardial infarction(Ml).Inspired by the 3D anisotropic characteristic of the natural fish swim bladder(FSB),a novel flexible,anisotropic,and conductive hydrogel was developed for tissue-specific adaptation to the anisotropic structural,conductive,and mechanical features of the native cardiac extracellular matrix.The results revealed that the originally stiff,homogeneous FSB film was tailored to a highly flexible anisotropic hydrogel,enabling its potential as a functional engineered cardiac patch(ECP).Invitro and in vivo experiments demonstrated the enhanced electrophysiological activity,maturation,elongation,and orientation of cardiomyocytes(CMs),and marked Ml repair performance with reduced CM apoptosis and myocardial fibrosis,thereby promoting cell retention,myogenesis,and vascularization,as well as improving electrical integration.Our findings offer a potential strategy for functional ECP and provides a novel strategy to bionically simulate the complex cardiac repair environment.
Central Laboratory,The Fifth Affiliated Hospital,Southern Medical University,Guangzhou,Guangdong 510910,China
Department of Anatomy,Neuroscience Laboratory for Cognitive and Developmental Disorders,Medical College of Jinan University,Guangzhou 510630,China
Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering,School of Basic Medical Science
Biomaterials Research Center,School of Biomedical Engineering,Southern Medical University,Guangzhou,Guangdong 510515,China
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国家自然科学基金国家自然科学基金国家自然科学基金国家自然科学基金国家自然科学基金Guangdong Basic and Applied Basic Research FoundationGuangdong Basic and Applied Basic Research FoundationMedical Research Project of Guangdong Province广东省自然科学基金Key Research and Development Program of Guangzhou Regenerative Medicine and Health Guangdong LaboratoryShenzhen Fundamental Research Key Project
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