首页|Acceptor Engineering Produces Ultrafast Nonradiative Decay in NIR-Ⅱ Aza-BODIPY Nanoparticles for Efficient Osteosarcoma Photothermal Therapy via Concurrent Apoptosis and Pyroptosis

Acceptor Engineering Produces Ultrafast Nonradiative Decay in NIR-Ⅱ Aza-BODIPY Nanoparticles for Efficient Osteosarcoma Photothermal Therapy via Concurrent Apoptosis and Pyroptosis

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
Small-molecule photothermal agents(PTAs)with intense second near-infrared(NIR-Ⅱ,1,000 to 1,700 nm)absorption and high photothermal conversion efficiencies(PCEs)are promising candidates for treating deep-seated tumors such as osteosarcoma.To date,the development of small-molecule NIR-Ⅱ PTAs has largely relied on fabricating donor-acceptor-donor(D-A-D/D')structures and limited success has been achieved.Herein,through acceptor engineering,a donor-acceptor-acceptor(D-A-A')-structured NIR-Ⅱ aza-boron-dipyrromethene(aza-BODIPY)PTA(SW8)was readily developed for the 1,064-nm laser-mediated phototheranostic treatment of osteosarcoma.Changing the donor groups to acceptor groups produced remarkable red-shifts of absorption maximums from first near-infrared(NIR-Ⅰ)regions(～808 nm)to NIR-Ⅱ ones(～1,064 nm)for aza-BODIPYs(SW1 to SW8).Furthermore,SW8 self-assembled into nanoparticles(SW8@NPs)with intense NIR-Ⅱ absorption and an ultrahigh PCE(75％,1,064 nm).This ultrahigh PCE primarily originated from an additional nonradiative decay pathway,which showed a 100-fold enhanced decay rate compared to that shown by conventional pathways such as internal conversion and vibrational relaxation.Eventually,SW8@NPs performed highly efficient 1,064-nm laser-mediated NIR-Ⅱ photothermal therapy of osteosarcoma via concurrent apoptosis and pyroptosis.This work not only illustrates a remote approach for treating deep-seated tumors with high spatiotemporal control but also provides a new strategy for building high-performance small-molecule NIR-Ⅱ PTAs.

Zhenxiong Shi、Hua Bai、Jiaxing Wu、Xiaofei Miao、Jia Gao、Xianning Xu、Yi Liu、Jiamin Jiang、Jiaqi Yang、Jiaxin Zhang、Tao Shao、Bo Peng、Huili Ma、Dan Zhu、Guojing Chen、Wenbo Hu、Lin Li、Wei Huang

展开 >

Frontiers Science Center for Flexible Electronics,Xi'an Institute of Flexible Electronics(IFE)and Xi'an Institute of Biomedical Materials & Engineering,Northwestern Polytechnical University,Xi'an 710072,China

Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials(IAM),Nanjing University of Posts & Telecommunications,Nanjing 210023,China

Key Laboratory of Flexible Electronics(KLOFE)and IAM,Nanjing Tech University,Nanjing 211800,China

Britton Chance Center for Biomedical Photonics-MoE Key Laboratory for Biomedical Photonics,Wuhan National Laboratory for Optoelectronics-Advanced Biomedical Imaging Facility,Huazhong University of Science and Technology,Wuhan 430074,China

Department of Orthopedics,Xijing Hospital,The Fourth Military Medical University,Xi'an 710032,China

The Institute of Flexible Electronics(IFE,Future Technologies),Xiamen University,Xiamen 361005,China

The Institute of Flexible Electr

展开 >

国家重点研发计划国家自然科学基金国家自然科学基金国家自然科学基金国家自然科学基金Joint Research Funds of Department of Science and Technology of Shaanxi Province and Northwestern Polytechnical UniversityJoint Research Funds of Department of Science and Technology of Shaanxi Province and Northwestern Polytechnical UniversityJoint Research Funds of Department of Science and Technology of Shaanxi Province and Northwestern Polytechnical UniversityOpen Project Program of Wuhan National Laboratory for OptoelectronicsOpen Project Program of Wuhan National Laboratory for Optoelectronics宁波市自然科学基金宁波市自然科学基金陕西省自然科学基金

2020YFA0709900622881022207710162175201220040992020GXLH-Z-0082020GXLH-Z-0212020GXLH-Z-0232020WNLOKF0232022WNLOKF009202003N4049202003N40652022JM-130

2024

10.34133/research.0169

研究(英文)

研究(英文)

CSTPCD
ISSN：
年,卷(期)：2024.2024(1)
  • 49