首页|Mulberry Biomass-Derived Nanomedicines Mitigate Colitis through Improved Inflamed Mucosa Accumulation and Intestinal Microenvironment Modulation

Mulberry Biomass-Derived Nanomedicines Mitigate Colitis through Improved Inflamed Mucosa Accumulation and Intestinal Microenvironment Modulation

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The therapeutic outcomes of conventional oral medications against ulcerative colitis(UC)are restricted by inefficient drug delivery to the colitis mucosa and weak capacity to modulate the inflammatory microenvironment.Herein,a fluorinated pluronic(FP127)was synthesized and employed to functionalize the surface of mulberry leaf-derived nanoparticles(MLNs)loading with resveratrol nanocrystals(RNs).The obtained FP127@RN-MLNs possessed exosome-like morphologies,desirable particle sizes(around 171.4 nm),and negatively charged surfaces(-14.8 mV).The introduction of FP127 to RN-MLNs greatly improved their stability in the colon and promoted their mucus infiltration and mucosal penetration capacities due to the unique fluorine effect.These MLNs could efficiently be internalized by colon epithelial cells and macrophages,reconstruct disrupted epithelial barriers,alleviate oxidative stress,provoke macrophage polarization to M2 phenotype,and down-regulate inflammatory responses.Importantly,in vivo studies based on chronic and acute UC mouse models demonstrated that oral administration of chitosan/alginate hydrogel-embedding FP127@RN-MLNs achieved substantially improved therapeutic efficacies compared with nonfluorinated MLNs and a first-line UC drug(dexamethasone),as evidenced by decreased colonic and systemic inflammation,integrated colonic tight junctions,and intestinal microbiota balance.This study brings new insights into the facile construction of a natural,versatile nanoplatform for oral treatment of UC without adverse effects.

Wenjing Yang、Ya Ma、Haiting Xu、.Zhenhua Zhu、Jiaxue Wu、Cheng Xu、Wei Sun、Erhu Zhao、Min Wang、Rui L.Reis、Subhas C.Kundu、Xiaoxiao Shi、Bo Xiao

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State Key Laboratory of Silkworm Genome Biology,College of Sericulture,Textile,and Biomass Sciences,Southwest University,Chongqing 400715,China

Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing,Faculty of Materials and Energy,Southwest University,Chongqing 400715,China

Department of Gastroenterology,The First Affiliated Hospital of Nanchang University,Nanchang 330006,China

3Bs Research Group,13Bs-Research Institute on Biomaterials,Biodegradables and Biomimetics,University of Minho,Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine,AvePark,Barco 4805-017,Guimaraes,Portugal

ICVS/3B's-PT Government Associate Laboratory,Braga,Guimarães,Portugal

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国家自然科学基金国家自然科学基金中央高校基本科研业务费专项Venture & Innovation Support Program for Chongqing Overseas Returnees重庆市自然科学基金Natural Science Foundation Project of Chongqing for Distinguished Young Scholar

8207206022008201SWU-XDPY220062205012980212766cstc2020jcyjmsxmX0292

2024

10.34133/research.0188

研究(英文)

研究(英文)

CSTPCD
ISSN：
年,卷(期)：2024.2024(1)
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