Precise Planar-Twisted Molecular Engineering to Construct Semiconducting Polymers with Balanced Absorption and Quantum Yield for Efficient Phototheranostics

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外文摘要：Semiconducting polymers(SPs)have shown great feasibility as candidates for near-infrared-ll(NIR-Ⅱ)fluorescence imaging-navigated photothermal therapy due to their strong light-harvesting ability and flexible tunability.However,the fluorescence signal of traditional SPs tends to quench in their aggregate states owing to the strong π-π stacking,which can lead to the radiative decay pathway shutting down.To address this issue,aggregation-induced emission effect has been used as a rational tactic to boost the aggregate-state fluorescence of NIR-Ⅱ emitters.In this contribution,we developed a precise molecular engineering tactic based on the block copolymerizations that integrate planar and twisted segments into one conjugated polymer backbone,providing great flexibility in tuning the photophysical properties and photothermal conversion capacity of SPs.Two monomers featured with twisted and planar architectures,respectively,were tactfully incorporated via a ternary copolymerization approach to produce a series of new SPs.The optimal copolymer(SP2)synchronously shows desirable absorption ability and good NIR-Ⅱ quantum yield on the premise of maintaining typical aggregation-induced emission characteristics,resulting in balanced NIR-Ⅱ fluorescence brightness and photothermal property.Water-dispersible nanoparticles fabricated from the optimal SP2 show efficient photothermal therapeutic effects both in vitro and in vivo.The in vivo investigation reveals the distinguished NIR-Ⅱ fluorescence imaging performance of SP2 nanoparticles and their photothermal ablation toward tumor with prominent tumor accumulation ability and excellent biocompatibility.

作者：

Xiang Su、Zhirong Bao、Wei Xie、Deliang Wang、Ting Han、Dong Wang、Ben Zhong Tang

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作者单位：

Center for AIE Research,Shenzhen Key Laboratory of Polymer Science and Technology,Guangdong Research Center for Interfacial Engineering of Functional Materials,College of Materials Science and Engineering,Shenzhen University,Shenzhen 518060,China

School of Biomedical and Pharmaceutical Sciences,Guangdong University of Technology,Guangzhou 510006,China

Department of Radiation and Medical Oncology,Hubei Key Laboratory of Tumor Biological Behaviors,Hubei Cancer Clinical Study Center,Zhongnan Hospital of Wuhan University,Wuhan 430071,China

Department of Materials Chemistry,Huzhou University,Huzhou 313000,China

School of Science and Engineering,Shenzhen Institute of Aggregate Science and Technology,The Chinese University of Hong Kong,Shenzhen,Guangdong 518172,China

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基金：

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaGuangdong Basic and Applied Basic Research FoundationGuangdong Basic and Applied Basic Research FoundationNatural Science Foundation for Distinguished Young Scholars of Guangdong ProvinceShenzhen Key Laboratory of Functional Aggregate MaterialsShenzhen Science and Technology ProgramShenzhen Science and Technology ProgramShenzhen Science and Technology ProgramShenzhen Science and Technology ProgramShenzhen Science and Technology Program

项目编号：

22271197222255062023A15150115782022A15151101462020B1515020011ZDSYS-20211021111400001RCYX20221008092924059JCYJ20220531102601003JCYJ20190808142403590KQTD20210811090142053JCYJ20220818

出版年：

2024

DOI：

10.34133/research.0194

研究(英文)

CSTPCD

ISSN：

年,卷(期)：2024.2024(2)

参考文献量58