首页|Supramolecular Biomaterials for Cancer Immunotherapy

Supramolecular Biomaterials for Cancer Immunotherapy

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Cancer immunotherapy has achieved tremendous successful clinical results and obtained historic victories in tumor treatments.However,great limitations associated with feeble immune responses and serious adverse effects still cannot be neglected due to the complicated multifactorial etiology and pathologic microenvironment in tumors.The rapid development of nanomedical science and material science has facilitated the advanced progress of engineering biomaterials to tackle critical issues.The supramolecular biomaterials with flexible and modular structures have exhibited unparalleled advantages of high cargo-loading efficiency,excellent biocompatibility,and diversiform immunomodulatory activity,thereby providing a powerful weapon for cancer immunotherapy.In past decades,supramolecular biomaterials were extensively explored as versatile delivery platforms for immunotherapeutic agents or designed to interact with the key moleculars in immune system in a precise and controllable manner.In this review,we focused on the crucial role of supramolecular biomaterials in the modulation of pivotal steps during tumor immunotherapy,including antigen delivery and presentation,T lymphocyte activation,tumor-associated macrophage elimination and repolarization,and myeloid-derived suppressor cell depletion.Based on extensive research,we explored the current limitations and development prospects of supramolecular biomaterials in cancer immunotherapy.

Huan Liang、Qingqing Lu、Jie Yang、Guocan Yu

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College of Science,Nanjing Forestry University,Nanjing 210037,P.R.China

Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology,Department of Chemistry,Tsinghua University,Beijing 100084,P.R.China

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaVanke Special Fund for Public Health and Health Discipline Development,Tsinghua UniversityVanke Special Fund for Public Health and Health Discipline Development,Tsinghua UniversityTsinghua University Spring Breeze FundStarry Night Science Fund of Zhejiang University Shanghai Institute for Advanced Study

22101134221751072022Z82WKJ0052022Z82WKJ0132021Z99CFZ007SN-ZJU-SIAS-006

2024

10.34133/research.0211

研究(英文)

研究(英文)

CSTPCD
ISSN：
年,卷(期)：2024.2024(2)
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