首页|Impaired Spatial Firing Representations of Neurons in the Medial Entorhinal Cortex of the Epileptic Rat Using Microelectrode Arrays

Impaired Spatial Firing Representations of Neurons in the Medial Entorhinal Cortex of the Epileptic Rat Using Microelectrode Arrays

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Epilepsy severely impairs the cognitive behavior of patients.It remains unclear whether epilepsy-induced cognitive impairment is associated with neuronal activities in the medial entorhinal cortex(MEC),a region known for its involvement in spatial cognition.To explore this neural mechanism,we recorded the spikes and local field potentials from MEC neurons in lithium-pilocarpine-induced epileptic rats using self-designed microelectrode arrays.Through the open field test,we identified spatial cells exhibiting spatially selective firing properties and assessed their spatial representations in relation to the progression of epilepsy.Meanwhile,we analyzed theta oscillations and theta modulation in both excitatory and inhibitory neurons.Furthermore,we used a novel object recognition test to evaluate changes in spatial cognitive ability of epileptic rats.After the epilepsy modeling,the spatial tuning of various types of spatial cells had suffered a rapid and pronounced damage during the latent period(1 to 5 d).Subsequently,the firing characteristics and theta oscillations were impaired.In the chronic period(＞10 d),the performance in the novel object experiment deteriorated.In conclusion,our study demonstrates the detrimental effect on spatial representations and electrophysiological properties of MEC neurons in the epileptic latency,suggesting the potential use of these changes as a"functional biomarker"for predicting cognitive impairment caused by epilepsy.

Zhaojie Xu、Fan Mo、Gucheng Yang、Penghui Fan、Botao Lu、Wei Liang、Fanli Kong、Luyi Jing、Wei Xu、Juntao Liu、Mixia Wang、Yirong Wu、Xinxia Cai

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State Key Laboratory of Transducer Technology,Aerospace Information Research Institute,Chinese Academy of Sciences,Beijing 100190,China

University of Chinese Academy of Sciences,Beijing 100049,China

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaFrontier Interdisciplinary Project of the Chinese Academy of SciencesNational Key Research and Development Program of ChinaNational Key Research and Development Program of ChinaMajor Program of Scientific and Technical Innovation 2030Scientific Instrument Developing Project of the Chinese Academy of Sciences

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2024

10.34133/research.0229

研究(英文)

研究(英文)

CSTPCD
ISSN：
年,卷(期)：2024.2024(2)
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