首页|Biomimetic Gland Models with Engineered Stratagems

Biomimetic Gland Models with Engineered Stratagems

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As extensively distributed tissues throughout the human body,glands play a critical role in various physiological processes.Therefore,the construction of biomimetic gland models in vitro has aroused great interest in multiple disciplines.In the biological field,the researchers focus on optimizing the cell sources and culture techniques to reconstruct the specific structures and functions of glands,such as the emergence of organoid technology.From the perspective of biomedical engineering,the generation of biomimetic gland models depends on the combination of engineered scaffolds and microfluidics,to mimic the in vivo environment of glandular tissues.These engineered stratagems endowed gland models with more biomimetic features,as well as a wide range of application prospects.In this review,we first describe the biomimetic strategies for constructing different in vitro gland models,focusing on the role of microfluidics in promoting the structure and function development of biomimetic glands.After summarizing several common in vitro models of endocrine and exocrine glands,the applications of gland models in disease modelling,drug screening,regenerative medicine,and personalized medicine are enumerated.Finally,we conclude the current challenges and our perspective of these biomimetic gland models.

Xiang Lin、Lingyu Sun、Minhui Lu、Yuanjin Zhao

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Department of Rheumatology and Immunology,Nanjing Drum Tower Hospital,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210096,China

Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine,Vision and Brain Health),Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou,Zhejiang 325001,China

Southeast University Shenzhen Research Institute,Shenzhen 518071,China

National Key Research and Development Program of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNanjing Medical Science and Technique Development FoundationClinical Trials from Nanjing Drum Tower HospitalGuangdong Basic and Applied Basic Research FoundationShenzhen Fundamental Research ProgramShenzhen Fundamental Research Program

2020YFA0908200T22250035207306061927805ZKX210192022-LCYJ-ZD-012021B1515120054JCYJ20190813152616459JCYJ20210324133214038

2024

10.34133/research.0232

研究(英文)

研究(英文)

CSTPCD
ISSN：
年,卷(期)：2024.2024(2)
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