首页|Sleep Promotion by 3-Hydroxy-4-lminobutyric Acid in Walnut Diaphragma juglandis Fructus

Sleep Promotion by 3-Hydroxy-4-lminobutyric Acid in Walnut Diaphragma juglandis Fructus

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Insufficient sleep can produce a multitude of deleterious repercussions on various domains of human well-being.Concomitantly,the walnut(Juglans mandshurica)confers numerous salutary biological activities pertaining to sleep.Nevertheless,the sedative and hypnotic capacities of walnut's functional constituents remain obscure.In this investigation,we analyzed the sedative and hypnotic components of the walnut Diaphragmajuglandis fructus and innovatively discovered a compound,defined as 3-hydroxy-4-iminobutyric acid(HI BA),which disrupts motor activity and enhances sleep duration by regulating the neurotransmitters(GABA,DA,etc.)within the brain and serum of mice.Subsequently,a metabolomics approach of the serum,basal ganglia,hypothalamus,and hippocampus as well as the gut microbiota was undertaken to unravel the underlying molecular mechanisms of sleep promotion.Our data reveal that HIBA can regulate the metabolism of basal ganglia(sphingolipids,acylcarnitines,etc.),possibly in relation to HIBA's influence on the gut microbiome(Muribaculum,Bacteroides,Lactobacillus,etc.).Therefore,we introduce a novel natural product,HIBA,and explicate the modulation of sleep promotion in mice based on the microbiota-gut-brain axis.This study contributes fresh insights toward natural product-based sleep research.

Jian Ji、Yongli Ye、Lina Sheng、Jiadi Sun、Qianqian Hong、Chang Liu、Jun Ding、Shuxiang Geng、Deping Xu、Yinzhi Zhang、Xiulan Sun

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State Key Laboratory of Food Science and Technology,School of Food Science and Technology,National Engineering Research Center for Functional Food,Synergetic Innovation Center of Food Safety and Quality Control,Jiangnan University,Lihu Avenue 1800,Wuxi,Jiangsu 214100,P.R.China

College of Food Science and Pharmacy,Xinjiang Agricultural University,No.311 Nongda Dong Road,Ürümqi,Xinjiang,Uygur Autonomous Region 830052,P.R.China

Department of Chemistry,Wuhan University,Wuhan,Hubei 430072,P.R.China

Yunnan Academy of Forestry and Grassland,Kunming,Yunnan 650201,P.R.China

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Key R&D program project of Yunnan ProvinceScience and Technology Project of Yunnan ProvinceScience and Technology Project of Chongzuo CityFundamental Research Funds for the Central UniversitiesCollaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province,Jiangnan University

202202AE090007202305AF15002520210710JUSRP222001

2024

10.34133/research.0216

研究(英文)

研究(英文)

CSTPCD
ISSN：
年,卷(期)：2024.2024(2)
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