首页|Imaging Carotid Plaque Burden in Living Mice via Hybrid Semiconducting Polymer Nanoparticles-Based Near-Infrared-Ⅱ Fluorescence and Magnetic Resonance Imaging

Imaging Carotid Plaque Burden in Living Mice via Hybrid Semiconducting Polymer Nanoparticles-Based Near-Infrared-Ⅱ Fluorescence and Magnetic Resonance Imaging

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The majority of atherothrombotic events(e.g.,cerebral or myocardial infarction)often occur as a result of plaque rupture or erosion in the carotid,and thereby it is urgent to assess plaque vulnerability and predict adverse cerebrovascular events.However,the monitoring evolution from stable plaque into life-threatening high-risk plaque in the slender carotid artery is a great challenge,due to not enough spatial resolution for imaging the carotid artery based on most of reported fluorescent probes.Herein,copolymerizing with the small molecules of acceptor-donor-acceptor-donor-acceptor(A-D-A'-D-A)and the electron-donating units(D'),the screened second near-infrared(NIR-Ⅱ)nanoprobe presents high quantum yield and good stability,so that it enables to image slender carotid vessel with enough spatial resolution.Encouragingly,NIR-Ⅱ nanoprobe can effectively target to intraplaque macrophage,meanwhile distinguishing vulnerable plaque in carotid atherosclerosis in living mice.Moreover,the NIR-Ⅱ nanoprobe can dynamically monitor the fresh bleeding spots in carotid plaque,indicating the increased risk of plaque instability.Besides,magnetic resonance imaging is integrated with NIR-Ⅱ fluorescence imaging to provide contrast for subtle structure(e.g.,narrow lumen and lipid pool),via incorporating ultrasmall superparamagnetic iron oxide into the NIR-Ⅱ nanoprobe.Thus,such hybrid NIR-Ⅱ/magnetic resonance imaging multimodal nanoprobe provides an effective tool for assessing carotid plaque burden,selecting high-risk plaque,and imaging intraplaque hemorrhage,which is promising for reducing cerebral/myocardial infarction-associated morbidity and mortality.

Li Xu、Zhe Li、Yuan Ma、Lingling Lei、Renye Yue、Hui Cao、Shuangyan Huan、Wei Sun、Guosheng Song

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State Key Laboratory for Chemo/Bio-Sensing and Chemometrics,College of Chemistry and Chemical Engineering,Engineering,Hunan University,Changsha 410082,China

Key Laboratory of Targeted Intervention of Cardiovascular Disease,Collaborative Innovation Center for Cardiovascular Disease Translational Medicine,Nanjing,Medical University

Department of Cardiology,The First Affiliated Hospital of Nanjing Medical University,Nanjing Medical University,Nanjing 210029,Jiangsu,China

2024

10.34133/research.0186

研究(英文)

研究(英文)

CSTPCD
ISSN：
年,卷(期)：2024.2024(3)