Neddylation Regulation of Immune Responses

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外文摘要：Neddylation plays a vital role in post-translational modification,intricately shaping the regulation of diverse biological processes,including those related to cellular immune responses.In fact,neddylation exerts control over both innate and adaptive immune systems via various mechanisms.Specifically,neddylation influences the function and survival of innate immune cells,activation of pattern recognition receptors and GMP-AMP synthase-stimulator of interferon genes pathways,as well as the release of various cytokines in innate immune reactions.Moreover,neddylation also governs the function and survival of antigen-presenting cells,which are crucial for initiating adaptive immune reactions.In addition,neddylation regulates T cell activation,proliferation,differentiation,survival,and their effector functions,thereby ensuring an appropriate adaptive immune response.In this review,we summarize the most recent findings in these aspects and delve into the connection between dysregulated neddylation events and immunological disorders,especially inflammatory diseases.Lastly,we propose future directions and potential treatments for these diseases by targeting neddylation.

作者：

Hongmei Mao、Xin Lin、Yi Sun

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作者单位：

Cancer Institute(Key Laboratory of Cancer Prevention and Intervention,China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational Medicine,Zhejiang University School of Medicine,Hangzhou 310029,China

Institute for Immunology,School of Medicine,Tsinghua University,Beijing 100084,China

Changping Laboratory,Beijing 102206,China

Cancer Center of Zhejiang University,Hangzhou 310029,China

Zhejiang Provincial Clinical Research Center for Cancer,Hangzhou,Zhejiang Province,China

Key Laboratory of Molecular Biology in Medical Sciences,Hangzhou,Zhejiang Province,China

Research Center for Life Science

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出版年：

2024

DOI：

10.34133/research.0283

研究(英文)

CSTPCD

ISSN：

年,卷(期)：2024.2024(3)